1 / 1 DeCS    
Descriptor English:   Platelet Activating Factor 
Descriptor Spanish:   Factor de Activación Plaquetaria 
Descriptor Portuguese:   Fator de Ativação de Plaquetas 
Synonyms English:   1 Alkyl 2 acetyl sn glycerophosphocholine
1-Alkyl-2-acetyl-sn-glycerophosphocholine
AGEPC
Acetyl Glyceryl Ether Phosphorylcholine
Aggregating Factor, Platelet
Factor, Platelet Activating
PAF Acether
PAF-Acether
Phosphorylcholine, Acetyl Glyceryl Ether
Platelet Activating Substance
Platelet Aggregating Factor
Platelet Aggregation Enhancing Factor
Platelet-Activating Substance
Thrombocyte Aggregating Activity  
Tree Number:   D02.033.100.291.211.500
D02.092.063.291.211.500
D02.092.877.883.333.710
D02.675.276.232.710
D10.570.755.375.760.400.985.910
D23.119.865
D23.469.050.600
Definition English:   A phospholipid derivative formed by PLATELETS; BASOPHILS; NEUTROPHILS; MONOCYTES; and MACROPHAGES. It is a potent platelet aggregating agent and inducer of systemic anaphylactic symptoms, including HYPOTENSION; THROMBOCYTOPENIA; NEUTROPENIA; and BRONCHOCONSTRICTION. 
History Note English:   1983(1979) 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AA analogs & derivatives
AN analysis AI antagonists & inhibitors
BI biosynthesis CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification DF deficiency
DE drug effects EC economics
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PH physiology
PO poisoning RE radiation effects
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UL ultrastructure UR urine
Record Number:   23518 
Unique Identifier:   D010972 


   CHEMICALS AND DRUGS [D]
      Organic Chemicals [D02]
         Alcohols [D02.033]
            Amino Alcohols [D02.033.100]
               Ethanolamines [D02.033.100.291]
                  Albuterol [D02.033.100.291.057] +
                  Choline [D02.033.100.291.211]
                     Platelet Activating Factor [D02.033.100.291.211.500] 
                  Clenbuterol [D02.033.100.291.231]
                  Deanol [D02.033.100.291.274]
                  Epinephrine [D02.033.100.291.310] +
                  Ethanolamine [D02.033.100.291.375]
                  2-Hydroxyphenethylamine [D02.033.100.291.410]
                  Formoterol Fumarate [D02.033.100.291.425] +
                  Isoproterenol [D02.033.100.291.439]
                  Labetalol [D02.033.100.291.460]
                  Metaproterenol [D02.033.100.291.465] +
                  Midodrine [D02.033.100.291.480]
                  Nebivolol [D02.033.100.291.491]
                  Norepinephrine [D02.033.100.291.502] +
                  Octopamine [D02.033.100.291.525]
                  Phenylephrine [D02.033.100.291.617] +
                  Procaterol [D02.033.100.291.630]
                  Sotalol [D02.033.100.291.805]
                  Synephrine [D02.033.100.291.870]
                  Terbutaline [D02.033.100.291.905]


   CHEMICALS AND DRUGS [D]
      Organic Chemicals [D02]
         Amines [D02.092]
            Amino Alcohols [D02.092.063]
               Ethanolamines [D02.092.063.291]
                  Albuterol [D02.092.063.291.057] +
                  Choline [D02.092.063.291.211]
                     Platelet Activating Factor [D02.092.063.291.211.500] 
                  Clenbuterol [D02.092.063.291.231]
                  Deanol [D02.092.063.291.274]
                  Epinephrine [D02.092.063.291.310] +
                  Ethanolamine [D02.092.063.291.375]
                  2-Hydroxyphenethylamine [D02.092.063.291.410]
                  Formoterol Fumarate [D02.092.063.291.425] +
                  Isoproterenol [D02.092.063.291.439]
                  Labetalol [D02.092.063.291.460]
                  Metaproterenol [D02.092.063.291.465] +
                  Midodrine [D02.092.063.291.480]
                  Nebivolol [D02.092.063.291.503]
                  Octopamine [D02.092.063.291.525]
                  Phenylephrine [D02.092.063.291.617] +
                  Procaterol [D02.092.063.291.647]
                  Sotalol [D02.092.063.291.805]
                  Synephrine [D02.092.063.291.870]
                  Terbutaline [D02.092.063.291.905]


   CHEMICALS AND DRUGS [D]
      Organic Chemicals [D02]
         Amines [D02.092]
            Quaternary Ammonium Compounds [D02.092.877]
               Trimethyl Ammonium Compounds [D02.092.877.883]
                  Betaine [D02.092.877.883.077]
                  Bethanechol Compounds [D02.092.877.883.088] +
                  Carnitine [D02.092.877.883.099] +
                  Cetrimonium Compounds [D02.092.877.883.111] +
                  Chlorisondamine [D02.092.877.883.222]
                  Chlormequat [D02.092.877.883.277]
                  Choline [D02.092.877.883.333]
                     Benzoylcholine [D02.092.877.883.333.100]
                     Carbachol [D02.092.877.883.333.115]
                     Cytidine Diphosphate Choline [D02.092.877.883.333.130]
                     Phosphorylcholine [D02.092.877.883.333.700]
                     Platelet Activating Factor [D02.092.877.883.333.710] 
                     Propylbenzilylcholine Mustard [D02.092.877.883.333.720]
                     Succinylcholine [D02.092.877.883.333.780]
                     Thiocholine [D02.092.877.883.333.800] +
                  Methacholine Compounds [D02.092.877.883.555] +
                  Muscarine [D02.092.877.883.777]


   CHEMICALS AND DRUGS [D]
      Organic Chemicals [D02]
         Onium Compounds [D02.675]
            Quaternary Ammonium Compounds [D02.675.276]
               Ambenonium Chloride [D02.675.276.046]
               Benzalkonium Compounds [D02.675.276.080]
               Benzethonium [D02.675.276.090]
               Bephenium Compounds [D02.675.276.102]
               Betaine [D02.675.276.125]
               Betalains [D02.675.276.136] +
               Bethanechol Compounds [D02.675.276.148] +
               Cetrimonium Compounds [D02.675.276.190] +
               Chlorisondamine [D02.675.276.200]
               Chlormequat [D02.675.276.207]
               (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride [D02.675.276.210]
               Choline [D02.675.276.232]
                  Benzoylcholine [D02.675.276.232.100]
                  Carbachol [D02.675.276.232.115]
                  Cytidine Diphosphate Choline [D02.675.276.232.130]
                  Phosphorylcholine [D02.675.276.232.700]
                  Platelet Activating Factor [D02.675.276.232.710] 
                  Propylbenzilylcholine Mustard [D02.675.276.232.720]
                  Succinylcholine [D02.675.276.232.780]
                  Thiocholine [D02.675.276.232.800] +
               Edrophonium [D02.675.276.352]
               Emepronium [D02.675.276.370]
               Gallamine Triethiodide [D02.675.276.400]
               Glycopyrrolate [D02.675.276.425]
               Hemicholinium 3 [D02.675.276.435]
               Lissamine Green Dyes [D02.675.276.475]
               Methacholine Compounds [D02.675.276.534] +
               Bis-Trimethylammonium Compounds [D02.675.276.558] +
               Methantheline [D02.675.276.569]
               Muscarine [D02.675.276.580]
               Neostigmine [D02.675.276.602]
               Oxyphenonium [D02.675.276.648]
               Propantheline [D02.675.276.700]
               Tetraethylammonium Compounds [D02.675.276.787] +
               Toxiferine [D02.675.276.844] +
               Tubocurarine [D02.675.276.922]


   CHEMICALS AND DRUGS [D]
      Lipids [D10]
         Membrane Lipids [D10.570]
            Phospholipids [D10.570.755]
               Glycerophosphates [D10.570.755.375]
                  Phosphatidic Acids [D10.570.755.375.760]
                     Glycerophospholipids [D10.570.755.375.760.400]
                        Glycerylphosphorylcholine [D10.570.755.375.760.400.386]
                        Phosphatidylcholines [D10.570.755.375.760.400.800] +
                        Phosphatidylethanolamines [D10.570.755.375.760.400.840]
                        Phosphatidylglycerols [D10.570.755.375.760.400.885] +
                        Phosphatidylinositols [D10.570.755.375.760.400.942] +
                        Phosphatidylserines [D10.570.755.375.760.400.971]
                        Phospholipid Ethers [D10.570.755.375.760.400.985]
                           Plasmalogens [D10.570.755.375.760.400.985.820]
                           Platelet Activating Factor [D10.570.755.375.760.400.985.910] 


   CHEMICALS AND DRUGS [D]
      Biological Factors [D23]
         Alarmins [D23.035]
         Antigens [D23.050] +
         Biomarkers [D23.101] +
         Blood Coagulation Factor Inhibitors [D23.113] +
         Blood Coagulation Factors [D23.119]
            beta-Thromboglobulin [D23.119.050]
            Calcium [D23.119.100]
            Factor V [D23.119.300] +
            Factor VII [D23.119.325] +
            Factor VIII [D23.119.350] +
            Factor IX [D23.119.375] +
            Factor X [D23.119.400] +
            Factor XI [D23.119.425] +
            Factor XII [D23.119.450] +
            Factor XIII [D23.119.475] +
            Fibrinogen [D23.119.490] +
            Fibrinopeptide A [D23.119.500]
            Fibrinopeptide B [D23.119.510]
            Kallikreins [D23.119.597] +
            Kininogens [D23.119.630] +
            Plasminogen Inactivators [D23.119.832] +
            Platelet Activating Factor [D23.119.865] 
            Platelet Factor 3 [D23.119.932]
            Platelet Factor 4 [D23.119.940]
            Prothrombin [D23.119.945]
            Thrombin [D23.119.960]
            Thromboplastin [D23.119.965]
            Tissue Plasminogen Activator [D23.119.970]
            von Willebrand Factor [D23.119.985]
         Chemotactic Factors [D23.125] +
         Host-Derived Cellular Factors [D23.297] +
         Inflammation Mediators [D23.469] +
         Intercellular Signaling Peptides and Proteins [D23.529] +
         Pathogen-Associated Molecular Pattern Molecules [D23.585]
         Pheromones [D23.641] +
         Phytochemicals [D23.704] +
         Pigments, Biological [D23.767] +
         Toxins, Biological [D23.946] +


   CHEMICALS AND DRUGS [D]
      Biological Factors [D23]
         Inflammation Mediators [D23.469]
            Autacoids [D23.469.050]
               Angiotensins [D23.469.050.050] +
               Eicosanoids [D23.469.050.175] +
               Histamine [D23.469.050.300]
               Kinins [D23.469.050.375] +
               Platelet Activating Factor [D23.469.050.600] 
               Serotonin [D23.469.050.650]
            Chemokines [D23.469.200] +
            Prostaglandins, Synthetic [D23.469.700] +