Search on: ALKYLATING AGENTS 
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Descriptor English:   Alkylating Agents 
Descriptor Spanish:   Alquilantes 
Descriptor Portuguese:   Alquilantes 
Synonyms English:   Agents, Alkylating
Alkylators  
Tree Number:   D27.505.519.124
D27.888.569.035
Definition English:   Highly reactive chemicals that introduce alkyl radicals into biologically active molecules and thereby prevent their proper functioning. Many are used as antineoplastic agents, but most are very toxic, with carcinogenic, mutagenic, teratogenic, and immunosuppressant actions. They have also been used as components in poison gases. 
History Note English:   66(64) 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AN analysis BL blood
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
EC economics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PO poisoning
RE radiation effects ST standards
SD supply & distribution TU therapeutic use
TO toxicity UR urine
Record Number:   479 
Unique Identifier:   D000477 

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