Search on: APOPTOSIS 
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Descriptor English:   Apoptosis 
Descriptor Spanish:   Apoptosis 
Descriptor Portuguese:   Apoptose 
Synonyms English:   Apoptoses, Extrinsic Pathway
Apoptoses, Intrinsic Pathway
Apoptosis, Extrinsic Pathway
Apoptosis, Intrinsic Pathway
Extrinsic Pathway Apoptoses
Extrinsic Pathway Apoptosis
Intrinsic Pathway Apoptoses
Intrinsic Pathway Apoptosis
Programmed Cell Death, Type I  
Tree Number:   G04.146.160
Definition English:   One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth. 
Indexing Annotation English:   do not confuse with NECROSIS, pathological cell death; unspecified probably goes here; PROGRAMMED CELL DEATH, TYPE II see AUTOPHAGY is also available
See Related English:   CARD Signaling Adaptor Proteins
Cellular Apoptosis Susceptibility Protein
Death Domain Receptor Signaling Adaptor Proteins
Genes, Transgenic, Suicide
In Situ Nick-End Labeling
History Note English:   93 
Allowable Qualifiers English:  
DE drug effects GE genetics
IM immunology PH physiology
RE radiation effects  
Record Number:   30827 
Unique Identifier:   D017209 

Occurrence in VHL: