Search on: APOPTOSIS INDUCING FACTOR 
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Descriptor English:   Apoptosis Inducing Factor 
Descriptor Spanish:   Factor Inductor de la Apoptosis 
Descriptor Portuguese:   Fator de Indução de Apoptose 
Synonyms English:   AIF Apoptosis Regulatory Protein
Apoptosis-Inducing Factor
Apoptosis-Inducing Factor, Mitochondrial
Mitochondrial Apoptosis Inducing Factor
Mitochondrial Apoptosis-Inducing Factor  
Tree Number:   D08.811.682.608.047
D12.644.360.075.311
D12.776.157.687.063
D12.776.331.161
D12.776.476.075.311
D12.776.660.720.063
Definition English:   A flavoprotein that functions as a powerful antioxidant in the MITOCHONDRIA and promotes APOPTOSIS when released from the mitochondria. In mammalian cells AIF is released in response to pro-apoptotic protein members of the bcl-2 protein family. It translocates to the CELL NUCLEUS and binds DNA to stimulate CASPASE-independent CHROMATIN condensation. 
Indexing Annotation English:   INHIBITOR OF APOPTOSIS PROTEINS is also available
History Note English:   2006(1999) 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AN analysis
AI antagonists & inhibitors BI biosynthesis
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification DF deficiency
DE drug effects EC economics
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PH physiology
PO poisoning RE radiation effects
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UL ultrastructure UR urine
Record Number:   50601 
Unique Identifier:   D051033 

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