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Descriptor English: Buprenorphine
Descriptor Spanish: Buprenorfina
Descriptor buprenorfina
Scope note: Derivado del alcaloide opiaceo TEBAÍNA, un analgésico más potente y con acción más prolongada que la MORFINA. Al parecer, actúa como agonista parcial en los receptores mu y kappa de opioides, y como antagonista de los receptores delta. La ausencia de actividad como agonista de los receptores delta se ha sugerido como causa de que, con el uso crónico de buprenorfina, no se produzca tolerancia.
Descriptor Portuguese: Buprenorfina
Descriptor French: Buprénorphine
Entry term(s): 6029 M
6029-M
6029M
Buprenex
Buprenorphine Hydrochloride
Buprex
Hydrochloride, Buprenorphine
Prefin
RX 6029 M
RX-6029-M
RX6029M
Subutex
Temgesic
Temgésic
Tree number(s): D03.132.577.249.150
D03.605.497.150
D03.633.400.686.150
D04.615.723.795.150
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D002047
Scope note: A derivative of the opioid alkaloid THEBAINE that is a more potent and longer lasting analgesic than MORPHINE. It appears to act as a partial agonist at mu and kappa opioid receptors and as an antagonist at delta receptors. The lack of delta-agonist activity has been suggested to account for the observation that buprenorphine tolerance may not develop with chronic use.
Annotation: for buprenorphine maintenance treatment, coordinate with OPIATE SUBSTITUTION TREATMENT
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Analgesics, Opioid
Narcotic Antagonists
Narcotics
Registry Number: 40D3SCR4GZ
CAS Type 1 Name: 6,14-Ethenomorphinan-7-methanol, 17-(cyclopropylmethyl)-alpha-(1,1-dimethylethyl)-4,5-epoxy-18,19-dihydro-3-hydroxy-6-methoxy-alpha-methyl-, (5alpha,7alpha(S))-
Previous Indexing: Dihydromorphinone (1966-1968)
Morphinans (1969-1978)
Morphine (1966-1968)
Public MeSH Note: 87; was see under MORPHINANS 1979-86
History Note: 87(79); was see under MORPHINANS 1979-86
Related: Opiate Substitution Treatment MeSH
DeCS ID: 2079
Unique ID: D002047
NLM Classification: QV 92
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1987/01/01
Date of Entry: 1978/03/17
Revision Date: 2017/05/24
Buprenorphine - Preferred
Concept UI M0003054
Scope note A derivative of the opioid alkaloid THEBAINE that is a more potent and longer lasting analgesic than MORPHINE. It appears to act as a partial agonist at mu and kappa opioid receptors and as an antagonist at delta receptors. The lack of delta-agonist activity has been suggested to account for the observation that buprenorphine tolerance may not develop with chronic use.
Preferred term Buprenorphine
Buprenex - Narrower
Concept UI M0352882
Preferred term Buprenex
Prefin - Narrower
Concept UI M0465414
Preferred term Prefin
Subutex - Narrower
Concept UI M0003053
Preferred term Subutex
Entry term(s) Buprex
Temgesic
Temgésic
6029-M - Narrower
Concept UI M0352881
Preferred term 6029-M
Entry term(s) 6029 M
6029M
RX 6029 M
RX-6029-M
RX6029M
Buprenorphine Hydrochloride - Narrower
Concept UI M0330887
Preferred term Buprenorphine Hydrochloride
Entry term(s) Hydrochloride, Buprenorphine



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