Search on: CARDIAC GLYCOSIDES 
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Descriptor English:   Cardiac Glycosides 
Descriptor Spanish:   Glicósidos Cardíacos 
Descriptor Portuguese:   Glicosídeos Cardíacos 
Synonyms English:   Cardiotonic Steroids
Glycosides, Cardiac
Steroids, Cardiotonic  
Tree Number:   D04.210.500.155.580
D09.408.180
Definition English:   Cyclopentanophenanthrenes with a 5- or 6-membered lactone ring attached at the 17-position and SUGARS attached at the 3-position. Plants they come from have long been used in congestive heart failure. They increase the force of cardiac contraction without significantly affecting other parameters, but are very toxic at larger doses. Their mechanism of action usually involves inhibition of the NA(+)-K(+)-EXCHANGING ATPASE and they are often used in cell biological studies for that purpose. 
Pharmacological Action:   Anti-Arrhythmia Agents
Cardiotonic Agents
Enzyme Inhibitors
 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AN analysis
AI antagonists & inhibitors BI biosynthesis
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification EC economics
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PO poisoning
RE radiation effects ST standards
SD supply & distribution TU therapeutic use
TO toxicity UR urine
Record Number:   2345 
Unique Identifier:   D002301 

Occurrence in VHL:
 
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MEDLINE    
MedCarib    

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