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Descriptor English: Cisplatin
Descriptor Spanish: Cisplatino
Descriptor cisplatino
Entry term(s) cis-diaminodicloroplatino(II)
cis-diclorodiaminoplatino(II)
diaminodicloruro de platino
Scope note: Complejo inorgánico de platino soluble en agua. Tras hidrólisis, reacciona con el ADN produciendo entrecruzamientos intra e intercatenarios. Estos entrecruzamientos alteran la replicación y transcripción del ADN. La citotoxicidad del cisplatino se correlaciona con la parada del ciclo celular en la fase G2.
Descriptor Portuguese: Cisplatino
Descriptor French: Cisplatine
Entry term(s): Biocisplatinum
Diamminodichloride, Platinum
Dichlorodiammineplatinum
NSC-119875
Platidiam
Platino
Platinol
Platinum Diamminodichloride
cis Diamminedichloroplatinum
cis Platinum
cis-Diamminedichloroplatinum
cis-Diamminedichloroplatinum(II)
cis-Dichlorodiammineplatinum(II)
cis-Platinum
Tree number(s): D01.210.375
D01.625.125
D01.710.100
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D002945
Scope note: An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity of cisplatin correlates with cellular arrest in the G2 phase of the cell cycle.
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Antineoplastic Agents
Cross-Linking Reagents
Radiation-Sensitizing Agents
Registry Number: Q20Q21Q62J
CAS Type 1 Name: Platinum, diamminedichloro-, (SP-4-2)-
Previous Indexing: Amines (1966-1973)
Ammonium Compounds (1966-1973)
Chlorides (1966-1973)
Platinum (1966-1973)
Public MeSH Note: 84; was see under DIAMMONIUM CHLOROPLATINUM COMPOUNDS 1981-83; was PLATINUM DIAMMINODICHLORIDE see under DIAMMONIUM CHLOROPLATINUM COMPOUNDS 1974-80; DIAMMONIUM CHLOROPLATINUM COMPOUNDS was heading 1974-83
Online Note: use CISPLATIN to search PLATINUM DIAMMINODICHLORIDE 1974-80 & DIAMMONIUM CHLOROPLATINUM COMPOUNDS 1974-83
History Note: 84(81); was see under DIAMMONIUM CHLOROPLATINUM COMPOUNDS 1981-83; was PLATINUM DIAMMINODICHLORIDE see under DIAMMONIUM CHLOROPLATINUM COMPOUNDS 1974-80; DIAMMONIUM CHLOROPLATINUM COMPOUNDS was heading 1974-83
DeCS ID: 2971
Unique ID: D002945
NLM Classification: QV 269
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1984/01/01
Date of Entry: 1999/01/01
Revision Date: 2013/07/08
Cisplatin - Preferred
Concept UI M0004505
Scope note An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity of cisplatin correlates with cellular arrest in the G2 phase of the cell cycle.
Preferred term Cisplatin
Entry term(s) Diamminodichloride, Platinum
Dichlorodiammineplatinum
Platinum Diamminodichloride
cis Diamminedichloroplatinum
cis Platinum
cis-Diamminedichloroplatinum
cis-Diamminedichloroplatinum(II)
cis-Dichlorodiammineplatinum(II)
cis-Platinum
NSC-119875 - Narrower
Concept UI M0373521
Preferred term NSC-119875
Platino - Narrower
Concept UI M0004508
Preferred term Platino
Platinol - Narrower
Concept UI M0004509
Preferred term Platinol
Biocisplatinum - Narrower
Concept UI M0004506
Preferred term Biocisplatinum
Platidiam - Narrower
Concept UI M0004507
Preferred term Platidiam



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