Search on: DIDEOXYADENOSINE 
Descriptors Found: 1
Displaying: 1 .. 1  

 1 / 1 DeCS     
Descriptor English:   Dideoxyadenosine 
Descriptor Spanish:   Didesoxiadenosina 
Descriptor Portuguese:   Didesoxiadenosina 
Synonyms English:   2',3' Dideoxyadenosine
2',3'-Dideoxyadenosine
ddA (Antiviral)  
Tree Number:   D03.633.100.759.590.138.325.105
D13.570.230.229.105
D13.570.230.500.105
D13.570.583.138.325.105
Definition English:   A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is an inhibitor of HIV replication, acting as a chain-terminator of viral DNA by binding to reverse transcriptase. Its principal side effect is nephrotoxicity. In vivo, dideoxyadenosine is rapidly metabolized to DIDANOSINE (ddI) by enzymatic deamination; ddI is then converted to dideoxyinosine monophosphate and ultimately to dideoxyadenosine triphosphate, the putative active metabolite. 
Indexing Annotation English:   an antiviral; inhibits HIV replication
Pharmacological Action:   Antimetabolites
Antiviral Agents
 
History Note English:   90 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AA analogs & derivatives
AN analysis AI antagonists & inhibitors
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification EC economics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PO poisoning RE radiation effects
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UR urine  
Record Number:   24602 
Unique Identifier:   D016048 

Occurrence in VHL:
 
LILACS    
MEDLINE    

Similar:

 
DeCS