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Descriptor English:   Fibroblast Growth Factor 1 
Descriptor Spanish:   Factor 1 de Crecimiento de Fibroblastos 
Descriptor Portuguese:   Fator 1 de Crescimento de Fibroblastos 
Synonyms English:   Acidic Fibroblast Growth Factor
Class I Heparin-Binding Growth Factor
Fibroblast Growth Factor, Acidic
Fibroblast Growth Factor-1
Heparin Binding Growth Factor, Class I
Heparin-Binding Fibroblast Growth Factor Class I
Heparin-Binding Growth Factor, Class I  
Tree Number:   D12.644.276.624.110
Definition English:   A 17-kDa single-chain polypeptide growth factor that plays a significant role in the process of WOUND HEALING and is a potent inducer of PHYSIOLOGIC ANGIOGENESIS. It binds to HEPARIN, which potentiates its biological activity and protects it from proteolysis. The growth factor is an extremely potent inducer of DNA synthesis in a variety of cell types from mesoderm and neuroectoderm lineages, and also has chemotactic and mitogenic activities. It was originally named acidic fibroblast growth factor based upon its chemical properties and to distinguish it from basic fibroblast growth factor (FIBROBLAST GROWTH FACTOR 2). 
History Note English:   2002(1991); for FIBROBLAST GROWTH FACTOR-1 use FIBROBLAST GROWTH FACTOR 1(NM) 1998-2001 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AA analogs & derivatives
AN analysis AI antagonists & inhibitors
BI biosynthesis BL blood
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
DF deficiency DE drug effects
EC economics GE genetics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PH physiology PO poisoning
RE radiation effects ST standards
SD supply & distribution TU therapeutic use
TO toxicity UL ultrastructure
UR urine  
Record Number:   28935 
Unique Identifier:   D016220 

Occurrence in VHL: