Search on: GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR 
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Descriptor English:   Granulocyte-Macrophage Colony-Stimulating Factor 
Descriptor Spanish:   Factor Estimulante de Colonias de Granulocitos y Macrófagos 
Descriptor Portuguese:   Fator Estimulador de Colônias de Granulócitos e Macrófagos 
Synonyms English:   CSF-2
CSF-GM
Cell-Stimulating Factor, Histamine-Producing
Colony Stimulating Factor, Granulocyte Macrophage
Colony-Stimulating Factor, Granulocyte-Macrophage
GM-CSF
Granulocyte Macrophage Colony Stimulating Factor
Histamine Producing Cell Stimulating Factor
Histamine-Producing Cell-Stimulating Factor
TC-GM-CSF
Tumor Cell Human GM Colony Stimulating Factor
Tumor-Cell Human GM Colony-Stimulating Factor  
Tree Number:   D12.644.276.374.410.240.375
D12.776.395.240.300
D12.776.467.374.410.240.375
D23.529.374.410.240.375
Definition English:   An acidic glycoprotein of MW 23 kDa with internal disulfide bonds. The protein is produced in response to a number of inflammatory mediators by mesenchymal cells present in the hemopoietic environment and at peripheral sites of inflammation. GM-CSF is able to stimulate the production of neutrophilic granulocytes, macrophages, and mixed granulocyte-macrophage colonies from bone marrow cells and can stimulate the formation of eosinophil colonies from fetal liver progenitor cells. GM-CSF can also stimulate some functional activities in mature granulocytes and macrophages. 
See Related English:   Receptors, Granulocyte-Macrophage Colony-Stimulating Factor
 
History Note English:   91; HISTAMINE-PRODUCING CELL-STIMULATING FACTOR was HISTAMINE-PRODUCING CELL STIMULATING FACTOR see INTERLEUKIN-3 1987-91 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AN analysis
AI antagonists & inhibitors BI biosynthesis
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification DF deficiency
DE drug effects EC economics
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PH physiology
PO poisoning RE radiation effects
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UL ultrastructure UR urine
Record Number:   28969 
Unique Identifier:   D016178 

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