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Descriptor English: Hexamethonium
Descriptor Spanish: Hexametonio
Descriptor hexametonio
Scope note: Antagonista colinérgico nicotínico frecuentemente referido como el bloqueante ganglionar prototipo. Se absorbe pobremente en el tubo digestivo y no cruza la barrera hematoencefálica. Se ha utilizado con diversos fines terapéuticos incluyendo la hipertensión pero, tal como los otros bloqueantes ganglionares, ha sido reemplazado por fármacos más efectivas en la mayoría de las indicaciones, aunque se utiliza ampliamente como herramienta experimental.
Descriptor Portuguese: Hexametônio
Descriptor French: Hexaméthonium
Entry term(s): Bitartrate, Hexamethonium
Bromide, Hexamethonium
Chloride, Hexamethonium
Depressin
Dibromide Dihydrate, Hexamethonium
Dibromide, Hexamethonium
Dichloride Dihydrate, Hexamethonium
Dihydrate, Hexamethonium Dibromide
Dihydrate, Hexamethonium Dichloride
Dihydroxide, Hexamethonium
Diiodide, Hexamethonium
Dimethylsulfate, Hexamethonium
Diperchlorate, Hexamethonium
Hexamethonium Bitartrate
Hexamethonium Bromide
Hexamethonium Chloride
Hexamethonium Dibromide
Hexamethonium Dibromide Dihydrate
Hexamethonium Dichloride Dihydrate
Hexamethonium Dihydroxide
Hexamethonium Diiodide
Hexamethonium Dimethylsulfate
Hexamethonium Diperchlorate
Hexamethonium Iodide
Hexamethonium Monotartrate
Hexonium
Iodide, Hexamethonium
Monotartrate, Hexamethonium
Tree number(s): D02.092.877.250.592.400
D02.675.276.558.592.500
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D018738
Scope note: A nicotinic cholinergic antagonist often referred to as the prototypical ganglionic blocker. It is poorly absorbed from the gastrointestinal tract and does not cross the blood-brain barrier. It has been used for a variety of therapeutic purposes including hypertension but, like the other ganglionic blockers, it has been replaced by more specific drugs for most purposes, although it is widely used a research tool.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Entry Combination: analogs & derivatives:Hexamethonium Compounds
Pharm Action: Antihypertensive Agents
Ganglionic Blockers
Nicotinic Antagonists
Registry Number: 3C9PSP36Z2
CAS Type 1 Name: 1,6-hexanediaminium, N,N,N,N',N',N'-hexamethyl-
Previous Indexing: Hexamethonium Compounds (1980-1994)
Public MeSH Note: 95; HEXAMETHONIUM was indexed under HEXAMETHONIUM COMPOUNDS 1980-94
Online Note: use HEXAMETHONIUM (NM) to search HEXAMETHONIUM 1980-94
History Note: 95; was HEXAMETHONIUM (NM) 1980-94
DeCS ID: 32201
Unique ID: D018738
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1995/01/01
Date of Entry: 1994/06/01
Revision Date: 2013/07/08
Hexamethonium - Preferred
Concept UI M0028070
Scope note A nicotinic cholinergic antagonist often referred to as the prototypical ganglionic blocker. It is poorly absorbed from the gastrointestinal tract and does not cross the blood-brain barrier. It has been used for a variety of therapeutic purposes including hypertension but, like the other ganglionic blockers, it has been replaced by more specific drugs for most purposes, although it is widely used a research tool.
Preferred term Hexamethonium
Entry term(s) Hexonium
Hexamethonium Dihydroxide - Narrower
Concept UI M0329168
Preferred term Hexamethonium Dihydroxide
Entry term(s) Dihydroxide, Hexamethonium
Hexamethonium Diiodide - Narrower
Concept UI M0329173
Preferred term Hexamethonium Diiodide
Entry term(s) Diiodide, Hexamethonium
Hexamethonium Dimethylsulfate - Narrower
Concept UI M0329169
Preferred term Hexamethonium Dimethylsulfate
Entry term(s) Dimethylsulfate, Hexamethonium
Hexamethonium Diperchlorate - Narrower
Concept UI M0329171
Preferred term Hexamethonium Diperchlorate
Entry term(s) Diperchlorate, Hexamethonium
Hexamethonium Iodide - Narrower
Concept UI M0028073
Preferred term Hexamethonium Iodide
Entry term(s) Iodide, Hexamethonium
Hexamethonium Dibromide Dihydrate - Narrower
Concept UI M0329166
Preferred term Hexamethonium Dibromide Dihydrate
Entry term(s) Dibromide Dihydrate, Hexamethonium
Dihydrate, Hexamethonium Dibromide
Depressin - Narrower
Concept UI M0351162
Preferred term Depressin
Hexamethonium Bitartrate - Narrower
Concept UI M0329165
Preferred term Hexamethonium Bitartrate
Entry term(s) Bitartrate, Hexamethonium
Hexamethonium Bromide - Narrower
Concept UI M0028071
Preferred term Hexamethonium Bromide
Entry term(s) Bromide, Hexamethonium
Hexamethonium Chloride - Narrower
Concept UI M0028072
Preferred term Hexamethonium Chloride
Entry term(s) Chloride, Hexamethonium
Hexamethonium Dibromide - Narrower
Concept UI M0329167
Preferred term Hexamethonium Dibromide
Entry term(s) Dibromide, Hexamethonium
Hexamethonium Dichloride Dihydrate - Narrower
Concept UI M0329164
Preferred term Hexamethonium Dichloride Dihydrate
Entry term(s) Dichloride Dihydrate, Hexamethonium
Dihydrate, Hexamethonium Dichloride
Hexamethonium Monotartrate - Narrower
Concept UI M0329172
Preferred term Hexamethonium Monotartrate
Entry term(s) Monotartrate, Hexamethonium



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