Search on: MITOGEN-ACTIVATED PROTEIN KINASES 
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Descriptor English:   Mitogen-Activated Protein Kinases 
Descriptor Spanish:   Proteínas Quinasas Activadas por Mitógenos 
Descriptor Portuguese:   Proteínas Quinases Ativadas por Mitógeno 
Synonyms English:   Kinases, Mitogen-Activated Protein
Mitogen Activated Protein Kinases
Protein Kinases, Mitogen-Activated  
Tree Number:   D08.811.913.696.620.682.700.567
D12.644.360.450
D12.776.476.450
Definition English:   A superfamily of PROTEIN-SERINE-THREONINE KINASES that are activated by diverse stimuli via protein kinase cascades. They are the final components of the cascades, activated by phosphorylation by MITOGEN-ACTIVATED PROTEIN KINASE KINASES, which in turn are activated by mitogen-activated protein kinase kinase kinases (MAP KINASE KINASE KINASES). 
See Related English:   MAP Kinase Signaling System
 
History Note English:   2000; for EXTRACELLULAR SIGNAL-REGULATED KINASES use CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE 1994-1999 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AN analysis AI antagonists & inhibitors
BI biosynthesis BL blood
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
DF deficiency DE drug effects
EC economics GE genetics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PH physiology PO poisoning
RE radiation effects ST standards
SD supply & distribution TU therapeutic use
TO toxicity UL ultrastructure
UR urine  
Record Number:   34450 
Unique Identifier:   D020928 

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