Search on: MIXED CONNECTIVE TISSUE DISEASE 
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Descriptor English:   Mixed Connective Tissue Disease 
Descriptor Spanish:   Enfermedad Mixta del Tejido Conjuntivo 
Descriptor Portuguese:   Doença Mista do Tecido Conjuntivo 
Synonyms English:   Connective Tissue Disease, Mixed
MCTD
Sharp Syndrome
Syndrome, Sharp  
Tree Number:   C17.300.540
Definition English:   A syndrome with overlapping clinical features of systemic lupus erythematosus, scleroderma, polymyositis, and Raynaud's phenomenon. The disease is differentially characterized by high serum titers of antibodies to ribonuclease-sensitive extractable (saline soluble) nuclear antigen and a "speckled" epidermal nuclear staining pattern on direct immunofluorescence. 
Indexing Annotation English:   a specific disease entity; do not confuse with CONNECTIVE TISSUE DISEASES
History Note English:   79 
Allowable Qualifiers English:  
BL blood CF cerebrospinal fluid
CI chemically induced CL classification
CO complications CN congenital
DI diagnosis DG diagnostic imaging
DH diet therapy DT drug therapy
EC economics EM embryology
EN enzymology EP epidemiology
EH ethnology ET etiology
GE genetics HI history
IM immunology ME metabolism
MI microbiology MO mortality
NU nursing PS parasitology
PA pathology PP physiopathology
PC prevention & control PX psychology
RT radiotherapy RH rehabilitation
SU surgery TH therapy
UR urine VE veterinary
VI virology  
Record Number:   9137 
Unique Identifier:   D008947 

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