Search on: MOTOR NEURON DISEASE 
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Descriptor English:   Motor Neuron Disease 
Descriptor Spanish:   Enfermedad de la Neurona Motora 
Descriptor Portuguese:   Doença dos Neurônios Motores 
Synonyms English:   Anterior Horn Cell Disease
Familial Motor Neuron Disease
Lateral Scleroses
Lateral Scleroses, Primary
Lateral Sclerosis
Lateral Sclerosis, Primary
Lower Motor Neuron Disease
Motor Neuron Disease, Familial
Motor Neuron Disease, Lower
Motor Neuron Disease, Secondary
Motor Neuron Disease, Upper
Motor Neuron Diseases
Motor System Disease
Motor System Diseases
Neuron Disease, Motor
Neuron Diseases, Motor
Primary Lateral Scleroses
Primary Lateral Sclerosis
Scleroses, Lateral
Scleroses, Primary Lateral
Sclerosis, Lateral
Sclerosis, Primary Lateral
Secondary Motor Neuron Disease
Upper Motor Neuron Disease  
Tree Number:   C10.574.562
C10.668.467
Definition English:   Diseases characterized by a selective degeneration of the motor neurons of the spinal cord, brainstem, or motor cortex. Clinical subtypes are distinguished by the major site of degeneration. In AMYOTROPHIC LATERAL SCLEROSIS there is involvement of upper, lower, and brainstem motor neurons. In progressive muscular atrophy and related syndromes (see MUSCULAR ATROPHY, SPINAL) the motor neurons in the spinal cord are primarily affected. With progressive bulbar palsy (BULBAR PALSY, PROGRESSIVE), the initial degeneration occurs in the brainstem. In primary lateral sclerosis, the cortical neurons are affected in isolation. (Adams et al., Principles of Neurology, 6th ed, p1089) 
Indexing Annotation English:   GEN or unspecified; prefer specifics
History Note English:   92 
Allowable Qualifiers English:  
BL blood CF cerebrospinal fluid
CI chemically induced CL classification
CO complications CN congenital
DI diagnosis DG diagnostic imaging
DH diet therapy DT drug therapy
EC economics EM embryology
EN enzymology EP epidemiology
EH ethnology ET etiology
GE genetics HI history
IM immunology ME metabolism
MI microbiology MO mortality
NU nursing PS parasitology
PA pathology PP physiopathology
PC prevention & control PX psychology
RT radiotherapy RH rehabilitation
SU surgery TH therapy
UR urine VE veterinary
VI virology  
Record Number:   29957 
Unique Identifier:   D016472 

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