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Descriptor English:   Neoplasm Proteins 
Descriptor Spanish:   Proteínas de Neoplasias 
Descriptor Portuguese:   Proteínas de Neoplasias 
Synonyms English:   Proteins, Neoplasm  
Tree Number:   D12.776.624
Definition English:   Proteins whose abnormal expression (gain or loss) are associated with the development, growth, or progression of NEOPLASMS. Some neoplasm proteins are tumor antigens (ANTIGENS, NEOPLASM), i.e. they induce an immune reaction to their tumor. Many neoplasm proteins have been characterized and are used as tumor markers (BIOMARKERS, TUMOR) when they are detectable in cells and body fluids as monitors for the presence or growth of tumors. Abnormal expression of ONCOGENE PROTEINS is involved in neoplastic transformation, whereas the loss of expression of TUMOR SUPPRESSOR PROTEINS is involved with the loss of growth control and progression of the neoplasm. 
Indexing Annotation English:   IM & coord with specific protein (IM) + specific histol type (IM) + specific organ/neoplasms term (IM); Manual
See Related English:   Antigens, Neoplasm
Biomarkers, Tumor
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AN analysis
AI antagonists & inhibitors BI biosynthesis
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification DF deficiency
DE drug effects EC economics
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PH physiology
PO poisoning RE radiation effects
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UL ultrastructure UR urine
Record Number:   9556 
Unique Identifier:   D009363 

Occurrence in VHL: