Search on: PARKINSON DISEASE 
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Descriptor English:   Parkinson Disease 
Descriptor Spanish:   Enfermedad de Parkinson 
Descriptor Portuguese:   Doença de Parkinson 
Synonyms English:   Idiopathic Parkinson Disease
Idiopathic Parkinson's Disease
Lewy Body Parkinson Disease
Lewy Body Parkinson's Disease
Paralysis Agitans
Parkinson Disease, Idiopathic
Parkinson's Disease
Parkinson's Disease, Idiopathic
Parkinson's Disease, Lewy Body
Parkinsonism, Primary
Primary Parkinsonism  
Tree Number:   C10.228.140.079.862.500
C10.228.662.600.400
C10.574.928.750
Definition English:   A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency to fall backwards), rigidity, stooped posture, slowness of voluntary movements, and a masklike facial expression. Pathologic features include loss of melanin containing neurons in the substantia nigra and other pigmented nuclei of the brainstem. LEWY BODIES are present in the substantia nigra and locus coeruleus but may also be found in a related condition (LEWY BODY DISEASE, DIFFUSE) characterized by dementia in combination with varying degrees of parkinsonism. (Adams et al., Principles of Neurology, 6th ed, p1059, pp1067-75) 
Indexing Annotation English:   drug ther: consider also ANTIPARKINSON AGENTS; /chem ind = PARKINSON DISEASE, SECONDARY/chem ind
Entry Combination - descr/qualif English:   Parkinson Disease/chemically induced use Parkinson Disease, Secondary/chemically induced
 
See Related English:   Lewy Bodies
 
History Note English:   1979(1963) 
Allowable Qualifiers English:  
BL blood CF cerebrospinal fluid
CL classification CO complications
CN congenital DI diagnosis
DG diagnostic imaging DH diet therapy
DT drug therapy EC economics
EM embryology EN enzymology
EP epidemiology EH ethnology
ET etiology GE genetics
HI history IM immunology
ME metabolism MI microbiology
MO mortality NU nursing
PS parasitology PA pathology
PP physiopathology PC prevention & control
PX psychology RT radiotherapy
RH rehabilitation SU surgery
TH therapy UR urine
VE veterinary VI virology
Record Number:   10489 
Unique Identifier:   D010300 

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