Search on: PERILIPINS 
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Descriptor English:   Perilipins 
Descriptor Spanish:   Perilipinas 
Descriptor Portuguese:   Perilipinas 
Synonyms English:   PAT Proteins
PLIN Proteins
Perilipin Adipophilin TIP47 Proteins
Perilipin Proteins
Perilipin-Adipophilin-TIP47 Proteins
Proteins, PAT
Proteins, PLIN
Proteins, Perilipin
Proteins, Perilipin-Adipophilin-TIP47  
Tree Number:   D12.776.157.464.500
Definition English:   A family of vertebrate and insect lipid droplet associated proteins. They consist of a conserved N-terminal PAT domain (an alpha-helical region of about 110 amino acids), an 11-mer repeat region, and lipid-binding hydrophobic regions or 4-helix bundles near their C-termini. Perilipins transiently or constitutively localize to LIPID DROPLETS in ADIPOCYTES and FOAM CELLS, especially in regions adjacent to the PLASMA MEMBRANE and ENDOPLASMIC RECTICULUM. They are critical for lipid droplet synthesis and homeostasis as well as the regulation of lipid metabolism. Genetic variations in perilipins are associated with ATHEROSCLEROSIS; OBESITY; and DIABETES MELLITUS. 
History Note English:   2017 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AN analysis
AI antagonists & inhibitors BI biosynthesis
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification DF deficiency
DE drug effects EC economics
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PH physiology
PO poisoning RE radiation effects
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UL ultrastructure UR urine
Record Number:   56570 
Unique Identifier:   D000070137 

Occurrence in VHL: