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Descriptor English: Podophyllotoxin
Descriptor Spanish: Podofilotoxina
Descriptor podofilotoxina
Entry term(s) epipodofilotoxina
Scope note: Lignano (LIGNANOS) que se encuentra en la resina PODOFILINO procedente de las raíces de las plantas PODOPHYLLUM. Es un potente veneno del huso, tóxico si se toma internamente, y que ha sido usado como catártico. Es muy irritante para la piel y membranas mucosas, tiene acciones queratolíticas, ha sido utilizado para tratar verrugas y queratosis y puede tener propiedades antineoplásicas, como algunos de sus congéneres y derivados.
Descriptor Portuguese: Podofilotoxina
Descriptor French: Podophyllotoxine
Entry term(s): CPH86
Condyline
Condylox
Epipodophyllotoxin
Podocon-25
Podofilm
Podofilox
Podophyllotoxin, (5R-(5 alpha,5a alpha,8a alpha,9 alpha))-Isomer
Podophyllotoxin, (5R-(5 alpha,5a alpha,8a alpha,9 beta))-Isomer
Podophyllotoxin, (5R-(5 alpha,5a alpha,8a beta,9 alpha))-Isomer
Podophyllotoxin, (5R-(5 alpha,5a beta,8a alpha,9 beta))-Isomer
Wartec
Warticon
Tree number(s): D02.455.426.559.389.140.450.777
D02.455.426.559.847.638.960.675
D04.615.638.960.675
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D011034
Scope note: A lignan (LIGNANS) found in PODOPHYLLIN resin from the roots of PODOPHYLLUM plants. It is a potent spindle poison, toxic if taken internally, and has been used as a cathartic. It is very irritating to skin and mucous membranes, has keratolytic actions, has been used to treat warts and keratoses, and may have antineoplastic properties, as do some of its congeners and derivatives.
Annotation: /biosyn permitted if by plant
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Antineoplastic Agents, Phytogenic
Keratolytic Agents
Tubulin Modulators
Registry Number: L36H50F353
CAS Type 1 Name: Furo(3',4':6,7)naphtho(2,3-d)-1,3-dioxol-6(5aH)-one, 5,8,8a,9-tetrahydro-9-hydroxy-5-(3,4,5-trimethoxyphenyl)-, (5R-(5alpha,5abeta,8aalpha,9alpha))-
Previous Indexing: Alkaloids (1966-1972)
Antineoplastic Agents (1966-1972)
Public MeSH Note: 73; EPIPODOPHYLLOTOXIN was see under PODOPHYLLOTOXIN 1975
Online Note: use PODOPHYLLOTOXIN to search EPIPODOPHYLLOTOXIN 1975
History Note: 73; EPIPODOPHYLLOTOXIN was see under PODOPHYLLOTOXIN 1975
DeCS ID: 11464
Unique ID: D011034
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1973/01/01
Date of Entry: 1999/01/01
Revision Date: 2016/07/01
Podophyllotoxin - Preferred
Concept UI M0017087
Scope note A lignan (LIGNANS) found in PODOPHYLLIN resin from the roots of PODOPHYLLUM plants. It is a potent spindle poison, toxic if taken internally, and has been used as a cathartic. It is very irritating to skin and mucous membranes, has keratolytic actions, has been used to treat warts and keratoses, and may have antineoplastic properties, as do some of its congeners and derivatives.
Preferred term Podophyllotoxin
Entry term(s) Podofilox
Condylox - Narrower
Concept UI M0369529
Preferred term Condylox
CPH86 - Related but not broader or narrower
Concept UI M0017089
Preferred term CPH86
Epipodophyllotoxin - Related but not broader or narrower
Concept UI M0017088
Preferred term Epipodophyllotoxin
Podocon-25 - Narrower
Concept UI M0475070
Preferred term Podocon-25
Podophyllotoxin, (5R-(5 alpha,5a alpha,8a alpha,9 beta))-Isomer - Narrower
Concept UI M0329868
Preferred term Podophyllotoxin, (5R-(5 alpha,5a alpha,8a alpha,9 beta))-Isomer
Podophyllotoxin, (5R-(5 alpha,5a alpha,8a beta,9 alpha))-Isomer - Narrower
Concept UI M0329803
Preferred term Podophyllotoxin, (5R-(5 alpha,5a alpha,8a beta,9 alpha))-Isomer
Podophyllotoxin, (5R-(5 alpha,5a beta,8a alpha,9 beta))-Isomer - Narrower
Concept UI M0329869
Preferred term Podophyllotoxin, (5R-(5 alpha,5a beta,8a alpha,9 beta))-Isomer
Wartec - Narrower
Concept UI M0475068
Preferred term Wartec
Entry term(s) Podofilm
Warticon
Condyline - Narrower
Concept UI M0475067
Preferred term Condyline
Podophyllotoxin, (5R-(5 alpha,5a alpha,8a alpha,9 alpha))-Isomer - Narrower
Concept UI M0329870
Preferred term Podophyllotoxin, (5R-(5 alpha,5a alpha,8a alpha,9 alpha))-Isomer



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