Search on: RENIN-ANGIOTENSIN SYSTEM 
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Descriptor English:   Renin-Angiotensin System 
Descriptor Spanish:   Sistema Renina-Angiotensina 
Descriptor Portuguese:   Sistema Renina-Angiotensina 
Synonyms English:   Renin Angiotensin Aldosterone System
Renin Angiotensin System
Renin-Angiotensin-Aldosterone System
System, Renin-Angiotensin
System, Renin-Angiotensin-Aldosterone  
Tree Number:   G03.820
G09.330.380.813
Definition English:   A BLOOD PRESSURE regulating system of interacting components that include RENIN; ANGIOTENSINOGEN; ANGIOTENSIN CONVERTING ENZYME; ANGIOTENSIN I; ANGIOTENSIN II; and angiotensinase. Renin, an enzyme produced in the kidney, acts on angiotensinogen, an alpha-2 globulin produced by the liver, forming ANGIOTENSIN I. Angiotensin-converting enzyme, contained in the lung, acts on angiotensin I in the plasma converting it to ANGIOTENSIN II, an extremely powerful vasoconstrictor. Angiotensin II causes contraction of the arteriolar and renal VASCULAR SMOOTH MUSCLE, leading to retention of salt and water in the KIDNEY and increased arterial blood pressure. In addition, angiotensin II stimulates the release of ALDOSTERONE from the ADRENAL CORTEX, which in turn also increases salt and water retention in the kidney. Angiotensin-converting enzyme also breaks down BRADYKININ, a powerful vasodilator and component of the KALLIKREIN-KININ SYSTEM. 
Indexing Annotation English:   note entry term but do not index under ALDOSTERONE unless particularly discussed
See Related English:   Angiotensin-Converting Enzyme Inhibitors
Kallikrein-Kinin System
 
History Note English:   82 
Allowable Qualifiers English:  
DE drug effects GE genetics
IM immunology PH physiology
RE radiation effects  
Record Number:   12506 
Unique Identifier:   D012084 

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