Search on: TISSUE DISTRIBUTION 
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Descriptor English:   Tissue Distribution 
Descriptor Spanish:   Distribución Tisular 
Descriptor Portuguese:   Distribuição Tecidual 
Synonyms English:   Distribution, Tissue
Distributions, Tissue
Tissue Distributions  
Tree Number:   G03.787.917
G07.690.725.949
Definition English:   Accumulation of a drug or chemical substance in various organs (including those not relevant to its pharmacologic or therapeutic action). This distribution depends on the blood flow or perfusion rate of the organ, the ability of the drug to penetrate organ membranes, tissue specificity, protein binding. The distribution is usually expressed as tissue to plasma ratios. 
Indexing Annotation English:   distrib of drugs or chem in organs & tissues; GEN only: not a substitute for organ /metab or organ /chem; never IM; coord NIM with substance /pharmacokin (IM) or /metab (IM)
History Note English:   78 
Allowable Qualifiers English:  
DE drug effects ES ethics
GE genetics IM immunology
PH physiology RE radiation effects
Record Number:   23482 
Unique Identifier:   D014018 

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