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Descriptor English: Connectin
Descriptor Spanish: Conectina
Descriptor conectina
Scope note: Proteína gigante elástica cuya masa molecular oscila entre 2.993 kDa (cardíaca), 3.300 kDa (psoas) y 3.700 kDa (sóleo) con un dominio cinasa. El amino terminal está implicado en la unión a la banda Z y la región carboxi terminal se une al filamento de miosina, existiendo solapamiento de los filamentos en la línea M.
Descriptor Portuguese: Conectina
Descriptor French: Connectine
Entry term(s): Kinase, Titin
M Band Proteins
M Line 185 kDa Protein
M-Band Proteins
M-Line 185 kDa Protein
M-Line Protein, Muscle
M-Protein (muscle)
Muscle M Line Protein
Muscle M-Line Protein
Myomesin
Protein, Muscle M-Line
Proteins, M-Band
Skelemins
Titin
Titin 1
Titin 2
Titin Kinase
alpha Connectin
alpha-Connectin
beta Connectin
beta-Connectin
Tree number(s): D08.811.913.696.620.682.324
D12.776.210.500.246
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D064211
Scope note: A giant elastic protein of molecular mass ranging from 2,993 kDa (cardiac), 3,300 kDa (psoas), to 3,700 kDa (soleus) having a kinase domain. The amino- terminal is involved in a Z line binding, and the carboxy-terminal region is bound to the myosin filament with an overlap between the counter-connectin filaments at the M line.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Public MeSH Note: 2014; was indexed under MUSCLE PROTEINS 1978-2013 and PROTEIN KINASES 198-2013
History Note: 2014
DeCS ID: 55298
Unique ID: D064211
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2014/01/01
Date of Entry: 2013/07/08
Revision Date: 2016/06/28
Connectin - Preferred
Concept UI M0064104
Scope note A giant elastic protein of molecular mass ranging from 2,993 kDa (cardiac), 3,300 kDa (psoas), to 3,700 kDa (soleus) having a kinase domain. The amino- terminal is involved in a Z line binding, and the carboxy-terminal region is bound to the myosin filament with an overlap between the counter-connectin filaments at the M line.
Preferred term Connectin
Titin Kinase - Narrower
Concept UI M0064103
Preferred term Titin Kinase
Entry term(s) Kinase, Titin
Titin
Myomesin - Related but not broader or narrower
Concept UI M0088397
Preferred term Myomesin
Entry term(s) M Band Proteins
M Line 185 kDa Protein
M-Band Proteins
M-Line 185 kDa Protein
M-Line Protein, Muscle
M-Protein (muscle)
Muscle M Line Protein
Muscle M-Line Protein
Protein, Muscle M-Line
Proteins, M-Band
Skelemins
alpha-Connectin - Narrower
Concept UI M0064098
Preferred term alpha-Connectin
Entry term(s) Titin 1
alpha Connectin
beta-Connectin - Narrower
Concept UI M0064099
Preferred term beta-Connectin
Entry term(s) Titin 2
beta Connectin



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