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Descriptor English: Dianhydrogalactitol
Descriptor Spanish: Dianhidrogalactitol
Descriptor dianhidrogalactitol
Entry term(s) NSC 132313
NSC-132313
NSC132313
dianhidrodulcitol
diepoxidulcitol
diepoxigalactitol
Scope note: Uno de los dihalohexitoles citotóxicos que produce alquilación y entrecruzamiento del ADN por medio de un grupo epóxido durante todas las fases del ciclo celular, causando una alteración de la función del ADN y la detención del ciclo celular. Tiene actividad antineoplásica y también causa toxicidad en la médula ósea.
Descriptor Portuguese: Dianidrogalactitol
Descriptor French: Dianhydro-galactitol
Entry term(s): 1,2,5,6-Dianhydrogalactitol
1,2-5,6-Dianhydrogalactitol
Dianhydrodulcitol
Diepoxydulcitol
Diepoxygalactitol
NSC 132313
NSC-132313
NSC132313
Tree number(s): D02.033.800.400.350
D09.853.400.350
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D003961
Scope note: One of the cytotoxic dihalohexitols that alkylates and cross-links DNA via an epoxide group during all phases of the cell cycle, resulting in a disruption of DNA function and cell cycle arrest. It has antineoplastic activity and also causes bone marrow toxicity.
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Antineoplastic Agents, Alkylating
Registry Number: 4S465RYF7M
CAS Type 1 Name: Galactitol, 1,2:5,6-dianhydro-
Previous Indexing: Alcohols (1966-1971)
Dulcitol (1972-1978)
Ethers, Cyclic (1966-1978)
Public MeSH Note: 91; was see under SUGAR ALCOHOLS 1979-90
History Note: 91(79); was see under SUGAR ALCOHOLS 1979-90
DeCS ID: 3988
Unique ID: D003961
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1991/01/01
Date of Entry: 1978/02/07
Revision Date: 2018/07/02
Dianhydrogalactitol - Preferred
Concept UI M0006206
Scope note One of the cytotoxic dihalohexitols that alkylates and cross-links DNA via an epoxide group during all phases of the cell cycle, resulting in a disruption of DNA function and cell cycle arrest. It has antineoplastic activity and also causes bone marrow toxicity.
Preferred term Dianhydrogalactitol
Entry term(s) 1,2,5,6-Dianhydrogalactitol
1,2-5,6-Dianhydrogalactitol
Dianhydrodulcitol
Diepoxydulcitol
Diepoxygalactitol
NSC-132313 - Narrower
Concept UI M0350698
Preferred term NSC-132313
Entry term(s) NSC 132313
NSC132313



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