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Descriptor English: Ionophores
Descriptor Spanish: Ionóforos
Descriptor ionóforos
Entry term(s) ionóforo
Scope note: Sustancias químicas que aumentan la permeabilidad a iones específicos de las membranas lipídicas biológicas o artificiales. La mayoría de los ionóforos son moléculas orgánicas relativamente pequeñas que actúan como transportadores móviles dentro de las membranas o que coalescen para formar canales permeables a iones a través de las membranas. Muchos son antibióticos y muchos actúan como desacopladores por medio de un cortocircuito del gradiente protónico a través de las membranas mitocondriales.
Descriptor Portuguese: Ionóforos
Descriptor French: Ionophores
Entry term(s): Ionophore
Tree number(s): D27.505.519.562.374
D27.720.395
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D007476
Scope note: Chemical agents that increase the permeability of biological or artificial lipid membranes to specific ions. Most ionophores are relatively small organic molecules that act as mobile carriers within membranes or coalesce to form ion permeable channels across membranes. Many are antibiotics, and many act as uncoupling agents by short-circuiting the proton gradient across mitochondrial membranes.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Previous Indexing: Antibiotics (1966-1975)
Biological Transport (1966-1975)
Uncoupling Agents (1972-1975)
Public MeSH Note: 76
History Note: 76
Related: Cell Membrane Permeability MeSH
DeCS ID: 7644
Unique ID: D007476
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1976/01/01
Date of Entry: 1975/07/25
Revision Date: 2020/05/27
Ionophores - Preferred
Concept UI M0011677
Scope note Chemical agents that increase the permeability of biological or artificial lipid membranes to specific ions. Most ionophores are relatively small organic molecules that act as mobile carriers within membranes or coalesce to form ion permeable channels across membranes. Many are antibiotics, and many act as uncoupling agents by short-circuiting the proton gradient across mitochondrial membranes.
Preferred term Ionophores
Entry term(s) Ionophore



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