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Descriptor English: Lopinavir
Descriptor Spanish: Lopinavir
Descriptor lopinavir
Scope note: Medicamento antiretroviral de la clase de los inhibidores de la proteasa utilizado como una combinación de dosis fija con RITONAVIR. Es también inhibidor de la CITOCROMO P-450 CYP3A.
Descriptor Portuguese: Lopinavir
Descriptor French: Lopinavir
Entry term(s): A 157378.0
A-157378.0
A157378.0
ABT 378
ABT-378
ABT378
N-(4-(((2,6-dimethylphenoxy)acetyl)amino)-3-hydroxy-5-phenyl-1-(phenylmethyl)pentyl)tetrahydro-alpha-(1-methylethyl)-2-oxo-1(2H)-pydrimidineacetamide
Tree number(s): D03.383.742.698.553
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D061466
Scope note: An HIV protease inhibitor used in a fixed-dose combination with RITONAVIR. It is also an inhibitor of CYTOCHROME P-450 CYP3A.
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: HIV Protease Inhibitors
Cytochrome P-450 CYP3A Inhibitors
Registry Number: 2494G1JF75
Public MeSH Note: 2012; LOPNAVIR was indexed under PYRIMIDINONES 2000-2011
History Note: 2012
DeCS ID: 54552
Unique ID: D061466
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2012/01/01
Date of Entry: 2011/06/27
Revision Date: 2016/07/01
Lopinavir - Preferred
Concept UI M0558541
Scope note An HIV protease inhibitor used in a fixed-dose combination with RITONAVIR. It is also an inhibitor of CYTOCHROME P-450 CYP3A.
Preferred term Lopinavir
Entry term(s) N-(4-(((2,6-dimethylphenoxy)acetyl)amino)-3-hydroxy-5-phenyl-1-(phenylmethyl)pentyl)tetrahydro-alpha-(1-methylethyl)-2-oxo-1(2H)-pydrimidineacetamide
A-157378.0 - Narrower
Concept UI M0406971
Preferred term A-157378.0
Entry term(s) A 157378.0
A157378.0
ABT 378 - Narrower
Concept UI M0289886
Preferred term ABT 378
Entry term(s) ABT-378
ABT378



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