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Descriptor English: Mibefradil
Descriptor Spanish: Mibefradil
Descriptor mibefradilo
Scope note: Tetralina sustituida con bencimidazoilo que se une selectivamente a los CANALES DEL CALCIO DE TIPO T y los inhibe.
Descriptor Portuguese: Mibefradil
Descriptor French: Mibéfradil
Entry term(s): Mibefradil Dihydrochloride
Posicor
Ro 40 5967
Ro 40-5967
Ro 405967
Tree number(s): D02.455.426.559.847.638.960.585
D03.633.100.103.618
D04.615.638.960.585
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D020748
Scope note: A benzimidazoyl-substituted tetraline that selectively binds and inhibits CALCIUM CHANNELS, T-TYPE.
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Antihypertensive Agents
Calcium Channel Blockers
Vasodilator Agents
Cytochrome P-450 CYP1A2 Inhibitors
Registry Number: 27B90X776A
CAS Type 1 Name: (1S,2S)-(2-((3-(2-benzimidazolyl)propyl)methylamino)ethyl)-6-fluoro-1,2,3,4-tetrahydro-1-isopropyl-2-naphthyl methoxyacetate
Previous Indexing: Benzimidazoles (1989-1999)
Tetrahydronaphthalenes (1989-1999)
Public MeSH Note: 2000; MIBEFRADIL was indexed under BENZIMIDAZOLES & TETRAHYDRONAPHTHALENS 1989-1999
History Note: 2000; use MIBEFRADIL 1989-1999
DeCS ID: 34398
Unique ID: D020748
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2000/01/01
Date of Entry: 1999/11/03
Revision Date: 2017/05/24
Mibefradil - Preferred
Concept UI M0167272
Scope note A benzimidazoyl-substituted tetraline that selectively binds and inhibits CALCIUM CHANNELS, T-TYPE.
Preferred term Mibefradil
Ro 40-5967 - Narrower
Concept UI M0167267
Preferred term Ro 40-5967
Entry term(s) Ro 40 5967
Ro 405967
Mibefradil Dihydrochloride - Narrower
Concept UI M0167270
Preferred term Mibefradil Dihydrochloride
Posicor - Narrower
Concept UI M0167271
Preferred term Posicor



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