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Descriptor English: Paxillin
Descriptor Spanish: Paxillin
Descriptor paxilina
Scope note: La paxilina es una proteína adaptadora de la transducción de señales que se limita a las ADHESIONES FOCALES por medio de sus cuatro dominios LIM. Experimenta una FOSFORILACIÓN en respuesta a la ADHESIÓN CELULAR mediada por integrinas e interactúa con diversas proteínas como son la VINCULINA, la CINASA DE ADHESIÓN FOCAL, la PROTEÍNA PROTOONCOGÉNICA PP60 (C-SRC) y la PROTEÍNA PROTOONCOGÉNICA C-CRK.
Descriptor Portuguese: Paxilina
Descriptor French: Paxilline
Tree number(s): D12.644.360.024.316
D12.776.157.057.092
D12.776.476.024.397
D12.776.512.374
D12.776.744.665
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D051419
Scope note: Paxillin is a signal transducing adaptor protein that localizes to FOCAL ADHESIONS via its four LIM domains. It undergoes PHOSPHORYLATION in response to integrin-mediated CELL ADHESION, and interacts with a variety of proteins including VINCULIN; FOCAL ADHESION KINASE; PROTO-ONCOGENE PROTEIN PP60(C-SRC); and PROTO-ONCOGENE PROTEIN C-CRK.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Public MeSH Note: 2006; PAXILLIN was indexed under CYTOSKELETAL PROTEINS & PHOSPHOPROTEINS 1991-2005
History Note: 2006(1991)
DeCS ID: 50780
Unique ID: D051419
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2006/01/01
Date of Entry: 2005/06/30
Revision Date: 2016/03/30
Paxillin - Preferred
Concept UI M0193207
Scope note Paxillin is a signal transducing adaptor protein that localizes to FOCAL ADHESIONS via its four LIM domains. It undergoes PHOSPHORYLATION in response to integrin-mediated CELL ADHESION, and interacts with a variety of proteins including VINCULIN; FOCAL ADHESION KINASE; PROTO-ONCOGENE PROTEIN PP60(C-SRC); and PROTO-ONCOGENE PROTEIN C-CRK.
Preferred term Paxillin



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