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Descriptor English: Quinine
Descriptor Spanish: Quinina
Descriptor quinina
Scope note: Alcaloide derivado de la corteza del árbol Cinchona. Es un fármaco antimalárico y constituye el ingrediente activo de los extractos de cinchona que se han utilizado para este propósito desde antes del 1633. La quinina es también un antipirético y analgésico suave y ha sido utilizado para estos propósitos en preparados contra el resfriado común. Otros usos de la quinina son: como agente amargante y odorizante y, en la actualidad, aún se utiliza en el tratamiento de la babesiosis. Además, la quinina es útil en algunas enfermedades musculares, especialmente calambres nocturnos de las piernas y miotonía congénita, debido a sus efectos directos sobre la membrana muscular y los canales de sodio. El mecanismo de sus efectos antimaláricos aún no se conocen bien.
Descriptor Portuguese: Quinina
Descriptor French: Quinine
Entry term(s): Biquinate
Bisulfate, Quinine
Hydrochloride, Quinine
Legatrim
Myoquin
Quinamm
Quinbisan
Quinbisul
Quindan
Quinimax
Quinine Bisulfate
Quinine Hydrochloride
Quinine Lafran
Quinine Sulfate
Quinine Sulphate
Quinine-Odan
Quinoctal
Quinson
Quinsul
Strema
Sulfate, Quinine
Sulphate, Quinine
Surquina
Tree number(s): D03.132.206.719
D03.605.687.762
D03.633.100.810.762
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D011803
Scope note: An alkaloid derived from the bark of the cinchona tree. It is used as an antimalarial drug, and is the active ingredient in extracts of the cinchona that have been used for that purpose since before 1633. Quinine is also a mild antipyretic and analgesic and has been used in common cold preparations for that purpose. It was used commonly and as a bitter and flavoring agent, and is still useful for the treatment of babesiosis. Quinine is also useful in some muscular disorders, especially nocturnal leg cramps and myotonia congenita, because of its direct effects on muscle membrane and sodium channels. The mechanisms of its antimalarial effects are not well understood.
Annotation: /biosyn permitted if by plant
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Antimalarials
Muscle Relaxants, Central
Analgesics, Non-Narcotic
Registry Number: A7V27PHC7A
CAS Type 1 Name: Cinchonan-9-ol, 6'-methoxy-, (8alpha,9R)-
DeCS ID: 12240
Unique ID: D011803
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1966/01/01
Date of Entry: 1999/01/01
Revision Date: 2017/05/24
Quinine - Preferred
Concept UI M0018346
Scope note An alkaloid derived from the bark of the cinchona tree. It is used as an antimalarial drug, and is the active ingredient in extracts of the cinchona that have been used for that purpose since before 1633. Quinine is also a mild antipyretic and analgesic and has been used in common cold preparations for that purpose. It was used commonly and as a bitter and flavoring agent, and is still useful for the treatment of babesiosis. Quinine is also useful in some muscular disorders, especially nocturnal leg cramps and myotonia congenita, because of its direct effects on muscle membrane and sodium channels. The mechanisms of its antimalarial effects are not well understood.
Preferred term Quinine
Quinimax - Narrower
Concept UI M0352772
Preferred term Quinimax
Quinine Bisulfate - Narrower
Concept UI M0018347
Preferred term Quinine Bisulfate
Entry term(s) Bisulfate, Quinine
Quinine Hydrochloride - Narrower
Concept UI M0018348
Preferred term Quinine Hydrochloride
Entry term(s) Hydrochloride, Quinine
Myoquin - Narrower
Concept UI M0475003
Preferred term Myoquin
Quinamm - Narrower
Concept UI M0475007
Preferred term Quinamm
Quinbisan - Narrower
Concept UI M0475004
Preferred term Quinbisan
Legatrim - Narrower
Concept UI M0475005
Preferred term Legatrim
Quinine Lafran - Narrower
Concept UI M0475000
Preferred term Quinine Lafran
Quinine Sulfate - Narrower
Concept UI M0018349
Preferred term Quinine Sulfate
Entry term(s) Quinine Sulphate
Sulfate, Quinine
Sulphate, Quinine
Quinine-Odan - Narrower
Concept UI M0475008
Preferred term Quinine-Odan
Quinoctal - Narrower
Concept UI M0475009
Preferred term Quinoctal
Surquina - Narrower
Concept UI M0475001
Preferred term Surquina
Biquinate - Narrower
Concept UI M0475002
Preferred term Biquinate
Strema - Narrower
Concept UI M0475010
Preferred term Strema
Quindan - Narrower
Concept UI M0352771
Preferred term Quindan
Quinbisul - Narrower
Concept UI M0475006
Preferred term Quinbisul
Entry term(s) Quinson
Quinsul



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