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Descriptor English: Simvastatin
Descriptor Spanish: Simvastatina
Descriptor simvastatina
Scope note: Derivado de la LOVASTATINA y potente inhibidor competitivo de la 3-hidroxi-3-metilglutaril coenzima A reductasa (HIDROXIMETILGLUTARIL COA REDUCTASAS), que es la enzima limitante de la velocidad de reacción en la biosíntesis del colesterol. Puede interferir también con la producción de hormonas esteroides. Debido a la inducción de RECEPTORES DE LDL hepáticos, aumenta la degradación del COLESTEROL LDL.
Descriptor Portuguese: Sinvastatina
Descriptor French: Simvastatine
Entry term(s): MK 733
MK-733
MK733
Synvinolin
Zocor
Tree number(s): D02.455.426.559.847.638.400.900
D04.615.638.400.900
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D019821
Scope note: A derivative of LOVASTATIN and potent competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HYDROXYMETHYLGLUTARYL COA REDUCTASES), which is the rate-limiting enzyme in cholesterol biosynthesis. It may also interfere with steroid hormone production. Due to the induction of hepatic LDL RECEPTORS, it increases breakdown of LDL CHOLESTEROL.
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Anticholesteremic Agents
Hypolipidemic Agents
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Registry Number: AGG2FN16EV
Previous Indexing: Lovastatin/analogs & derivatives (1988-1997)
Naphthalenes (1986-1987)
Public MeSH Note: 98; SIMVASTATIN was indexed under LOVASTATIN/analogs & derivatives 1988-97 & NAPHTHALENES 1986-87
History Note: 98; use SIMVASTATIN (NM) 1986-97
Related: Rosuvastatin Calcium MeSH
DeCS ID: 33420
Unique ID: D019821
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1998/01/01
Date of Entry: 1997/06/20
Revision Date: 2017/01/17
Simvastatin - Preferred
Concept UI M0029425
Scope note A derivative of LOVASTATIN and potent competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HYDROXYMETHYLGLUTARYL COA REDUCTASES), which is the rate-limiting enzyme in cholesterol biosynthesis. It may also interfere with steroid hormone production. Due to the induction of hepatic LDL RECEPTORS, it increases breakdown of LDL CHOLESTEROL.
Preferred term Simvastatin
Zocor - Narrower
Concept UI M0029426
Preferred term Zocor
MK-733 - Narrower
Concept UI M0350853
Preferred term MK-733
Entry term(s) MK 733
MK733
Synvinolin - Narrower
Concept UI M000623516
Preferred term Synvinolin



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