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Descriptor English: Spironolactone
Descriptor Spanish: Espironolactona
Descriptor espironolactona
Entry term(s) espirolactona
Scope note: Diurético que conserva potasio y que actúa como antagonista de la aldosterona en los túbulos renales distales. Se utiliza principalmente en el tratamiento del edema refractario en pacientes con insuficiencia cardíaca congestiva, síndrome nefrótico o cirrosis hepática. Se utilizan sus efectos sobre el sistema endocrino en los tratamientos del hirsutismo y acné pero pueden llevar a reacciones adversas. (Martindale, The Extra Pharmacopoeia, 30th ed, p827)
Descriptor Portuguese: Espironolactona
Descriptor French: Spironolactone
Entry term(s): Aldactone
Aldactone A
Aquareduct
Ct, Spiro Von
Duraspiron
Espironolactona Alter
Espironolactona Mundogen
Flumach
Frumikal
Jenaspiron
Novo Spiroton
Novo-Spiroton
NovoSpiroton
Practon
SC 9420
SC-9420
SC9420
Spiractin
Spiro L.U.T.
Spiro Von Ct
Spirobeta
Spirogamma
Spirolactone
Spirolang
Spirono Isis
Spirono-Isis
Spironone
Spirospare
Veroshpiron
Verospiron
Verospirone
Von Ct, Spiro
Tree number(s): D02.540.679
D04.210.500.745.745.855
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D013148
Scope note: A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Mineralocorticoid Receptor Antagonists
Diuretics
Registry Number: 27O7W4T232
CAS Type 1 Name: Pregn-4-ene-21-carboxylic acid, 7-(acetylthio)-17-hydroxy-3-oxo-, gamma-lactone, (7alpha,17alpha)-
DeCS ID: 13531
Unique ID: D013148
NLM Classification: QV 160
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1966/01/01
Date of Entry: 1999/01/01
Revision Date: 2017/05/24
Spironolactone - Preferred
Concept UI M0020352
Scope note A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)
Preferred term Spironolactone
Entry term(s) Spirolactone
Veroshpiron
Verospirone
Spiractin - Narrower
Concept UI M0475755
Preferred term Spiractin
Spirobeta - Narrower
Concept UI M0475758
Preferred term Spirobeta
Spirogamma - Narrower
Concept UI M0475775
Preferred term Spirogamma
Spirolang - Narrower
Concept UI M0351544
Preferred term Spirolang
Spirono-Isis - Narrower
Concept UI M0475838
Preferred term Spirono-Isis
Entry term(s) Spirono Isis
Spironone - Narrower
Concept UI M0475776
Preferred term Spironone
Spirospare - Narrower
Concept UI M0475777
Preferred term Spirospare
Aldactone - Narrower
Concept UI M0020353
Preferred term Aldactone
Verospiron - Narrower
Concept UI M0475837
Preferred term Verospiron
Aldactone A - Narrower
Concept UI M0020354
Preferred term Aldactone A
Aquareduct - Narrower
Concept UI M0475746
Preferred term Aquareduct
Duraspiron - Narrower
Concept UI M0475747
Preferred term Duraspiron
Espironolactona Alter - Narrower
Concept UI M0475748
Preferred term Espironolactona Alter
Espironolactona Mundogen - Narrower
Concept UI M0475749
Preferred term Espironolactona Mundogen
Flumach - Narrower
Concept UI M0475750
Preferred term Flumach
Frumikal - Narrower
Concept UI M0475751
Preferred term Frumikal
Jenaspiron - Narrower
Concept UI M0475752
Preferred term Jenaspiron
Novo-Spiroton - Narrower
Concept UI M0475753
Preferred term Novo-Spiroton
Entry term(s) Novo Spiroton
NovoSpiroton
Practon - Narrower
Concept UI M0475754
Preferred term Practon
SC-9420 - Narrower
Concept UI M0351543
Preferred term SC-9420
Entry term(s) SC 9420
SC9420
Spiro L.U.T. - Narrower
Concept UI M0475756
Preferred term Spiro L.U.T.
Spiro Von Ct - Narrower
Concept UI M0475757
Preferred term Spiro Von Ct
Entry term(s) Ct, Spiro Von
Von Ct, Spiro



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