Descriptors Found: 1
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Descriptor English:   4-Hydroxycoumarins 
Descriptor Spanish:   4-Hidroxicumarinas 
Descriptor Portuguese:   4-Hidroxicumarinas 
Synonyms English:   4 Hydroxycoumarins  
Tree Number:   D03.383.663.283.446.520
Definition English:   Substances found in many plants, containing the 4-hydroxycoumarin radical. They interfere with vitamin K and the blood clotting mechanism, are tightly protein-bound, inhibit mitochondrial and microsomal enzymes, and are used as oral anticoagulants. 
Indexing Annotation English:   /biosyn permitted if by plant
Pharmacological Action:   Anticoagulants
Enzyme Inhibitors
History Note English:   77 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AN analysis
AI antagonists & inhibitors BI biosynthesis
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification EC economics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PO poisoning RE radiation effects
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UR urine  
Record Number:   7056 
Unique Identifier:   D015110 

Occurrence in VHL: