Search on: ALKB ENZYMES 
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Descriptor English:   AlkB Enzymes 
Descriptor Spanish:   Enzimas AlkB 
Descriptor Portuguese:   Enzimas AlkB 
Synonyms English:   AlkB Homologs
Alkylated DNA Repair Protein AlkB Homologs
Alkylation Repair Homolog Proteins
Alkylation Repair Homologs
Enzymes, AlkB  
Tree Number:   D08.811.074.062
Definition English:   A family of alpha- KETOGLUTARIC ACID and Fe(II)-dependent dioxygenases that are homologous to AlkB, an enzyme that repairs alkylated nucleic acids in E. coli. The mammalian homologs have diverse substrate specificities and functions that include DNA REPAIR, generating unique wobble modifications in URIDINE tRNA, demethylation of nucleotides in DNA and RNA, and demethylation of LYSINE residues on certain proteins, including ACTIN and histones (HISTONE CODE). 
History Note English:   2017 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AN analysis AI antagonists & inhibitors
BI biosynthesis BL blood
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
DF deficiency DE drug effects
EC economics GE genetics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PH physiology PO poisoning
RE radiation effects ST standards
SD supply & distribution TU therapeutic use
TO toxicity UL ultrastructure
UR urine  
Record Number:   56458 
Unique Identifier:   D000071496 

Occurrence in VHL: