| Descriptor English: | Angiotensinogen | ||||||
| Descriptor Spanish: |
Angiotensinógeno
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| Descriptor Portuguese: | Angiotensinogênio | ||||||
| Descriptor French: | Angiotensinogène | ||||||
| Entry term(s): |
Hypertensinogen Proangiotensin Renin Substrate Renin Substrate Tetradecapeptide Renin-Substrate SERPINA8 Serpin A8 Tetradecapeptide, Renin Substrate |
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| Tree number(s): |
D12.644.456.073.070 D12.644.861.020 D12.776.811.070 D12.776.872.020 |
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| RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D000808 | ||||||
| Scope note: | An alpha-globulin of about 453 amino acids, depending on the species. It is produced by the liver in response to lowered blood pressure and secreted into blood circulation. Angiotensinogen is the inactive precursor of the ANGIOTENSINS produced in the body by successive enzyme cleavages. Cleavage of angiotensinogen by RENIN yields the decapeptide ANGIOTENSIN I. Further cleavage of angiotensin I (by ANGIOTENSIN CONVERTING ENZYME) yields the potent vasoconstrictor octapeptide ANGIOTENSIN II; and then, via other enzymes, other angiotensins also involved in the hemodynamic-regulating RENIN-ANGIOTENSIN SYSTEM. |
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| Allowable Qualifiers: |
AD administration & dosage AE adverse effects AG agonists AI antagonists & inhibitors AN analysis BI biosynthesis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis DE drug effects DF deficiency EC economics GE genetics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PH physiology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UL ultrastructure UR urine |
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| Pharm Action: |
Serine Proteinase Inhibitors |
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| Registry Number: | 11002-13-4 | ||||||
| CAS Type 1 Name: | Angiotensinogen (protein renin substrate) | ||||||
| Previous Indexing: |
Alpha Globulins (1968-1974) Angiotensin II (1968-1974) Protein Precursors (1971-1974) |
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| Public MeSH Note: | 87; was see under ANGIOTENSINS 1975-86 |
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| History Note: | 87(75); was see under ANGIOTENSINS 1975-86 |
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| DeCS ID: | 27913 | ||||||
| Unique ID: | D000808 | ||||||
| NLM Classification: | QU 68 | ||||||
| Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||||
| Date Established: | 1987/01/01 | ||||||
| Date of Entry: | 1974/11/19 | ||||||
| Revision Date: | 2020/06/09 |
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CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins
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Angiotensinogen
- Preferred
Renin Substrate Tetradecapeptide
- Narrower
| Concept UI |
M0001208 |
| Scope note | An alpha-globulin of about 453 amino acids, depending on the species. It is produced by the liver in response to lowered blood pressure and secreted into blood circulation. Angiotensinogen is the inactive precursor of the ANGIOTENSINS produced in the body by successive enzyme cleavages. Cleavage of angiotensinogen by RENIN yields the decapeptide ANGIOTENSIN I. Further cleavage of angiotensin I (by ANGIOTENSIN CONVERTING ENZYME) yields the potent vasoconstrictor octapeptide ANGIOTENSIN II; and then, via other enzymes, other angiotensins also involved in the hemodynamic-regulating RENIN-ANGIOTENSIN SYSTEM. |
| Preferred term | Angiotensinogen |
| Entry term(s) |
Hypertensinogen Proangiotensin Renin Substrate Renin-Substrate SERPINA8 Serpin A8 |
| Concept UI |
M0001209 |
| Scope note | A synthetic or processed 14-amino acid peptide that is used to measure RENIN activities. |
| Preferred term | Renin Substrate Tetradecapeptide |
| Entry term(s) |
Tetradecapeptide, Renin Substrate |
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