Search on: ANOCTAMINS 
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Descriptor English:   Anoctamins 
Descriptor Spanish:   Anoctaminas 
Descriptor Portuguese:   Anoctaminas 
Synonyms English:   Anoctamin
Protein Family, TMEM16
TMEM16 Protein Family
TMEM16 Proteins  
Tree Number:   D12.776.157.530.400.175.032
Definition English:   A family of transmembrane proteins that function primarily as calcium-activated chloride channels. Structurally, they form a homodimer where each subunit consists of eight transmembrane helices with the N and C terminals exposed to the cytosol. The regions between helices 5 and 7 may be important for ion pore formation and calcium ion binding. 
History Note English:   2018 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AN analysis
AI antagonists & inhibitors BI biosynthesis
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification DF deficiency
DE drug effects EC economics
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PH physiology
PO poisoning RE radiation effects
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UL ultrastructure UR urine
Record Number:   57079 
Unique Identifier:   D000075368 

Occurrence in VHL: