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Descriptor English: Aprotinin
Descriptor Spanish: Aprotinina
Descriptor aprotinina
Entry term(s) inactivador de calicreína-tripsina
inhibidor de la tripsina de Kunitz pancreática
inhibidor de la tripsina pancreática bovina de Kunitz
inhibidor de la tripsina pancreática básica
inhibidor de la tripsina pancreática básica BPTI
inhibidor de la tripsina pancreática de Kunitz
inhibidor de tripsina básica pancreática
Scope note: Polipéptido monocatenario derivado de tejidos bovinos que consta de 58 residuos de aminoácidos. Es inhibidor de las enzimas proteolíticas como QUIMOTRIPSINA, CALICREÍNA, PLASMINA y TRIPSINA. Se utiliza en el tratamiento de la HEMORRAGIA asociada con elevaciones plasmáticas altas de plasmina. Se emplea también para reducir la pérdida de sangre y los requerimientos transfusionales en los pacientes en riesgo alto de pérdida sanguínea importante y después de cirugía a corazón abierto con CIRCULACIÓN EXTRACORPÓREA. (Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Englewood, CO, 1995)
Descriptor Portuguese: Aprotinina
Descriptor French: Aprotinine
Entry term(s): Antilysin
BPTI, Basic Pancreatic Trypsin Inhibitor
Basic Pancreatic Trypsin Inhibitor
Bovine Kunitz Pancreatic Trypsin Inhibitor
Bovine Pancreatic Trypsin Inhibitor
Contrical
Contrykal
Dilmintal
Inactivator, Kallikrein-Trypsin
Iniprol
Kallikrein Trypsin Inactivator
Kallikrein-Trypsin Inactivator
Kontrikal
Kontrykal
Kunitz Pancreatic Trypsin Inhibitor
Pulmin
Traskolan
Trasylol
Trypsin Inhibitor, Basic, Pancreatic
Trypsin Inhibitor, Kunitz, Pancreatic
Zymofren
Tree number(s): D12.776.083
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D007611
Scope note: A single-chain polypeptide derived from bovine tissues consisting of 58 amino-acid residues. It is an inhibitor of proteolytic enzymes including CHYMOTRYPSIN; KALLIKREIN; PLASMIN; and TRYPSIN. It is used in the treatment of HEMORRHAGE associated with raised plasma concentrations of plasmin. It is also used to reduce blood loss and transfusion requirements in patients at high risk of major blood loss during and following open heart surgery with EXTRACORPOREAL CIRCULATION. (Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Englewood, CO, 1995)
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Pharm Action: Hemostatics
Trypsin Inhibitors
Serine Proteinase Inhibitors
Registry Number: 9087-70-1
Public MeSH Note: 90; was KALLIKREIN-TRYPSIN INACTIVATOR 1966-89
Online Note: use APROTININ to search KALLIKREIN-TRYPSIN INACTIVATOR 1966-89
History Note: 90; was KALLIKREIN-TRYPSIN INACTIVATOR 1966-89
DeCS ID: 28294
Unique ID: D007611
NLM Classification: QU 143
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1966/01/01
Date of Entry: 1999/01/01
Revision Date: 2016/07/01
Aprotinin - Preferred
Concept UI M0011905
Scope note A single-chain polypeptide derived from bovine tissues consisting of 58 amino-acid residues. It is an inhibitor of proteolytic enzymes including CHYMOTRYPSIN; KALLIKREIN; PLASMIN; and TRYPSIN. It is used in the treatment of HEMORRHAGE associated with raised plasma concentrations of plasmin. It is also used to reduce blood loss and transfusion requirements in patients at high risk of major blood loss during and following open heart surgery with EXTRACORPOREAL CIRCULATION. (Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Englewood, CO, 1995)
Preferred term Aprotinin
Entry term(s) BPTI, Basic Pancreatic Trypsin Inhibitor
Basic Pancreatic Trypsin Inhibitor
Bovine Kunitz Pancreatic Trypsin Inhibitor
Bovine Pancreatic Trypsin Inhibitor
Inactivator, Kallikrein-Trypsin
Kallikrein Trypsin Inactivator
Kallikrein-Trypsin Inactivator
Kunitz Pancreatic Trypsin Inhibitor
Trypsin Inhibitor, Basic, Pancreatic
Trypsin Inhibitor, Kunitz, Pancreatic
Pulmin - Narrower
Concept UI M0011914
Preferred term Pulmin
Traskolan - Narrower
Concept UI M0011915
Preferred term Traskolan
Dilmintal - Narrower
Concept UI M0011910
Preferred term Dilmintal
Zymofren - Narrower
Concept UI M0011916
Preferred term Zymofren
Antilysin - Narrower
Concept UI M0011907
Preferred term Antilysin
Contrykal - Narrower
Concept UI M0011909
Preferred term Contrykal
Entry term(s) Contrical
Kontrikal
Kontrykal
Iniprol - Narrower
Concept UI M0011911
Preferred term Iniprol
Trasylol - Related but not broader or narrower
Concept UI M0011906
Preferred term Trasylol



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