Search on: ARGININOSUCCINATE SYNTHASE 
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Descriptor English:   Argininosuccinate Synthase 
Descriptor Spanish:   Argininosuccinato Sintasa 
Descriptor Portuguese:   Argininossuccinato Sintase 
Synonyms English:   Argininosuccinate Synthetase
Synthase, Argininosuccinate
Synthetase, Argininosuccinate  
Tree Number:   D08.811.464.259.300
Definition English:   An enzyme of the urea cycle that catalyzes the formation of argininosuccinic acid from citrulline and aspartic acid in the presence of ATP. Absence or deficiency of this enzyme causes the metabolic disease CITRULLINEMIA in humans. EC 6.3.4.5. 
Indexing Annotation English:   /defic: consider also CITRULLINEMIA
See Related English:   Citrullinemia
 
History Note English:   98(75) 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AN analysis AI antagonists & inhibitors
BI biosynthesis BL blood
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
DF deficiency DE drug effects
EC economics GE genetics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PH physiology PO poisoning
RE radiation effects ST standards
SD supply & distribution TU therapeutic use
TO toxicity UL ultrastructure
UR urine  
Record Number:   1127 
Unique Identifier:   D001124 

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