Search on: AROMATASE 
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Descriptor English:   Aromatase 
Descriptor Spanish:   Aromatasa 
Descriptor Portuguese:   Aromatase 
Synonyms English:   Androstenedione Aromatase
Aromatase, Androstenedione
CYP 19
CYP19
CYP19 Protein
Cytochrome P 450 CYP19
Cytochrome P-450 CYP19
Cytochrome P-450(AROM)
Cytochrome P450 19
Estrogen Synthase
Estrogen Synthetase
P450AROM
Protein, CYP19  
Tree Number:   D08.244.453.489.500
D08.244.453.915.099
D08.811.682.690.708.170.447.500
D08.811.682.690.708.170.915.099
D12.776.422.220.453.489.500
D12.776.422.220.453.915.099
Definition English:   An enzyme that catalyzes the desaturation (aromatization) of the ring A of C19 androgens and converts them to C18 estrogens. In this process, the 19-methyl is removed. This enzyme is membrane-bound, located in the endoplasmic reticulum of estrogen-producing cells of ovaries, placenta, testes, adipose, and brain tissues. Aromatase is encoded by the CYP19 gene, and functions in complex with NADPH-FERRIHEMOPROTEIN REDUCTASE in the cytochrome P-450 system. 
Entry Combination - descr/qualif English:   Aromatase/antagonists & inhibitors use Aromatase Inhibitors
 
History Note English:   86(75); was see under OXIDOREDUCTASES 1975-85 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AN analysis BI biosynthesis
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification DF deficiency
DE drug effects EC economics
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PH physiology
PO poisoning RE radiation effects
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UL ultrastructure UR urine
Record Number:   23161 
Unique Identifier:   D001141 

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MEDLINE    
BBO    
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