| Descriptor English: | Ataxins | ||||||
| Descriptor Spanish: |
Ataxinas
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| Descriptor Portuguese: | Ataxinas | ||||||
| Descriptor French: | Ataxines | ||||||
| Entry term(s): |
Ataxia Protein, Spinocerebellar Ataxia Proteins, Spinocerebellar Ataxin Ataxin Protein Ataxin Proteins Protein, Ataxin Protein, Spinocerebellar Ataxia Proteins, Ataxin Proteins, Spinocerebellar Ataxia Spinocerebellar Ataxia Protein Spinocerebellar Ataxia Proteins |
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| Tree number(s): |
D12.776.631.069 D12.776.660.075 |
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| RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D000067528 | ||||||
| Scope note: | A family of predominantly nuclear proteins that regulate gene transcription and protein degradation. The expansion of CAG trinucleotide repeats in genes that encode Ataxins is associated with SPINOCEREBELLAR ATAXIAS (SCA). In SCA patients, the number of CAG repeats correlates with the severity of disease and inversely correlates with the age of disease onset. |
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| Allowable Qualifiers: |
AD administration & dosage AE adverse effects AG agonists AI antagonists & inhibitors AN analysis BI biosynthesis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis DE drug effects DF deficiency EC economics GE genetics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PH physiology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UL ultrastructure UR urine |
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| Previous Indexing: |
Nerve Tissue Proteins (1995-2015) Nuclear Proteins (1995-2015) |
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| Public MeSH Note: | 2016 |
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| History Note: | 2016 |
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| Related: |
Spinocerebellar Ataxias
MeSH | ||||||
| DeCS ID: | 56001 | ||||||
| Unique ID: | D000067528 | ||||||
| Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||||
| Date Established: | 2016/01/01 | ||||||
| Date of Entry: | 2015/07/06 | ||||||
| Revision Date: | 2020/05/27 |
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CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins
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Ataxins
- Preferred
| Concept UI |
M000599991 |
| Scope note | A family of predominantly nuclear proteins that regulate gene transcription and protein degradation. The expansion of CAG trinucleotide repeats in genes that encode Ataxins is associated with SPINOCEREBELLAR ATAXIAS (SCA). In SCA patients, the number of CAG repeats correlates with the severity of disease and inversely correlates with the age of disease onset. |
| Preferred term | Ataxins |
| Entry term(s) |
Ataxia Protein, Spinocerebellar Ataxia Proteins, Spinocerebellar Ataxin Ataxin Protein Ataxin Proteins Protein, Ataxin Protein, Spinocerebellar Ataxia Proteins, Ataxin Proteins, Spinocerebellar Ataxia Spinocerebellar Ataxia Protein Spinocerebellar Ataxia Proteins |
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