| Descriptor English: | Bestrophins | ||||||
| Descriptor Spanish: |
Bestrofinas
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| Descriptor Portuguese: | Bestrofinas | ||||||
| Descriptor French: | Bestrophines | ||||||
| Entry term(s): |
BEST 1 Protein BEST 2 Protein BEST-1 Protein BEST-2 Protein Bestrophin Bestrophin 1 Bestrophin 2 Bestrophin Family Bestrophin Proteins Bestrophin-1 Bestrophin-2 |
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| Tree number(s): |
D12.776.157.530.400.175.063 D12.776.306.228 D12.776.543.550.450.175.063 D12.776.543.585.400.175.063 |
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| RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D000075002 | ||||||
| Scope note: | A protein family characterized by a highly conserved N-terminus and four to six transmembrane helices; they function as bicarbonate permeable, calcium-activated chloride channels. Bestrophin-1 (BEST-1) and bestrophin-2 are highly expressed in human RETINAL PIGMENT EPITHELIUM cells and mutations in the BEST-1 gene are associated with VITELLIFORM MACULAR DYSTROPHY, TYPE 2. |
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| Allowable Qualifiers: |
AD administration & dosage AE adverse effects AG agonists AI antagonists & inhibitors AN analysis BI biosynthesis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis DE drug effects DF deficiency EC economics GE genetics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PH physiology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UL ultrastructure UR urine |
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| Previous Indexing: |
Chloride Channels (1999-2017) Eye Proteins (1999-2017) |
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| Public MeSH Note: | 2018 |
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| History Note: | 2018 |
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| DeCS ID: | 57081 | ||||||
| Unique ID: | D000075002 | ||||||
| Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||||
| Date Established: | 2018/01/01 | ||||||
| Date of Entry: | 2017/07/11 | ||||||
| Revision Date: | 2017/05/22 |
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CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins
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Bestrophins
- Preferred
Bestrophin-1
- Narrower
Bestrophin-2
- Narrower
| Concept UI |
M000628883 |
| Scope note | A protein family characterized by a highly conserved N-terminus and four to six transmembrane helices; they function as bicarbonate permeable, calcium-activated chloride channels. Bestrophin-1 (BEST-1) and bestrophin-2 are highly expressed in human RETINAL PIGMENT EPITHELIUM cells and mutations in the BEST-1 gene are associated with VITELLIFORM MACULAR DYSTROPHY, TYPE 2. |
| Preferred term | Bestrophins |
| Entry term(s) |
Bestrophin Bestrophin Family Bestrophin Proteins |
| Concept UI |
M000628886 |
| Preferred term | Bestrophin-1 |
| Entry term(s) |
BEST 1 Protein BEST-1 Protein Bestrophin 1 |
| Concept UI |
M000628887 |
| Preferred term | Bestrophin-2 |
| Entry term(s) |
BEST 2 Protein BEST-2 Protein Bestrophin 2 |
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