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Descriptor English: Bromouracil
Descriptor Spanish: Bromouracilo
Descriptor bromouracilo
Scope note: 5-bromo-2,4(1H,3H)-pirimidindiona. Derivado bromado de uracilo que actúa como antimetabolito, sustituyendo la timina en el ADN. Se utiliza, primordialmente, como mutágeno experimental, aunque su desoxirribosa (BROMODESOXIURIDINA) se utiliza para tratamiento de neoplasias.
Descriptor Portuguese: Bromouracila
Descriptor French: Bromouracil
Entry term(s): 5 Bromouracil
5-Bromouracil
Bromuracil
Tree number(s): D03.383.742.698.875.237
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D001976
Scope note: 5-Bromo-2,4(1H,3H)-pyrimidinedione. Brominated derivative of uracil that acts as an antimetabolite, substituting for thymine in DNA. It is used mainly as an experimental mutagen, but its deoxyriboside (BROMODEOXYURIDINE) is used to treat neoplasms.
Annotation: an antimetabolite
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Antimetabolites
Mutagens
Registry Number: 4HK400G5UO
CAS Type 1 Name: 2,4(1H,3H)-Pyrimidinedione, 5-bromo-
Previous Indexing: Uracil (1966-1970)
Public MeSH Note: 74
History Note: 74(71)
DeCS ID: 2006
Unique ID: D001976
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1974/01/01
Date of Entry: 1999/01/01
Revision Date: 2016/05/27
Bromouracil - Preferred
Concept UI M0002954
Scope note 5-Bromo-2,4(1H,3H)-pyrimidinedione. Brominated derivative of uracil that acts as an antimetabolite, substituting for thymine in DNA. It is used mainly as an experimental mutagen, but its deoxyriboside (BROMODEOXYURIDINE) is used to treat neoplasms.
Preferred term Bromouracil
Entry term(s) 5 Bromouracil
5-Bromouracil
Bromuracil



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