Search on: BUPRENORPHINE 
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Descriptor English:   Buprenorphine 
Descriptor Spanish:   Buprenorfina 
Descriptor Portuguese:   Buprenorfina 
Synonyms English:   6029 M
6029-M
6029M
Buprenex
Buprenorphine Hydrochloride
Buprex
Hydrochloride, Buprenorphine
Prefin
RX 6029 M
RX-6029-M
RX6029M
Subutex
Temgesic
Temgésic  
Tree Number:   D03.132.577.249.150
D03.605.497.150
D03.633.400.686.150
D04.615.723.795.150
Definition English:   A derivative of the opioid alkaloid THEBAINE that is a more potent and longer lasting analgesic than MORPHINE. It appears to act as a partial agonist at mu and kappa opioid receptors and as an antagonist at delta receptors. The lack of delta-agonist activity has been suggested to account for the observation that buprenorphine tolerance may not develop with chronic use. 
Indexing Annotation English:   for buprenorphine maintenance treatment, coordinate with OPIATE SUBSTITUTION TREATMENT
Pharmacological Action:   Analgesics, Opioid
Narcotic Antagonists
Narcotics
 
See Related English:   Opiate Substitution Treatment
 
History Note English:   87(79); was see under MORPHINANS 1979-86 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AA analogs & derivatives
AN analysis AI antagonists & inhibitors
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification EC economics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PO poisoning RE radiation effects
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UR urine  
Record Number:   2079 
Unique Identifier:   D002047 

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