Descriptors Found: 1
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 1 / 1 DeCS     
Descriptor English:   Central Nervous System Agents 
Descriptor Spanish:   Fármacos del Sistema Nervioso Central 
Descriptor Portuguese:   Fármacos do Sistema Nervoso Central 
Synonyms English:   Central Nervous System Drugs  
Tree Number:   D27.505.954.427
Definition English:   A class of drugs producing both physiological and psychological effects through a variety of mechanisms. They can be divided into "specific" agents, e.g., affecting an identifiable molecular mechanism unique to target cells bearing receptors for that agent, and "nonspecific" agents, those producing effects on different target cells and acting by diverse molecular mechanisms. Those with nonspecific mechanisms are generally further classed according to whether they produce behavioral depression or stimulation. Those with specific mechanisms are classed by locus of action or specific therapeutic use. (From Gilman AG, et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p252) 
Indexing Annotation English:   GEN or unspecified; prefer specific groups or specific drugs; consider also CENTRAL NERVOUS SYSTEM /drug eff & BRAIN /drug eff; DF: CNS AGENTS
History Note English:   79; was NON MESH before 1979 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AN analysis
AI antagonists & inhibitors BL blood
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
EC economics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PO poisoning
RE radiation effects ST standards
SD supply & distribution TU therapeutic use
TO toxicity UR urine
Record Number:   2526 
Unique Identifier:   D002491 

Occurrence in VHL: