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Descriptor English: Chlorambucil
Descriptor Spanish: Clorambucilo
Descriptor clorambucilo
Entry term(s) clorambucil
Scope note: Agente alquilante derivado de la mostaza nitrogenada que se utiliza como antineoplásico en la leucemia linfocítica crónica, enfermedad de Hodgkin y otras. Aunque es menos tóxico que la mayoría de las otras mostazas nitrogenadas, ha quedado listado como carcinógeno conocido en el Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
Descriptor Portuguese: Clorambucila
Descriptor French: Chlorambucil
Entry term(s): 4-(Bis(2-chloroethyl)amino)benzenebutanoic Acid
Amboclorin
CB 1348
CB-1348
CB1348
Chloraminophene
Chlorbutin
Leukeran
Lympholysin
N,N-Di-(2-chloroethyl)-p-aminophenylbutyric Acid
NSC 3088
NSC-3088
NSC3088
Tree number(s): D02.455.526.728.650.156
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D002699
Scope note: A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Antineoplastic Agents, Alkylating
Registry Number: 18D0SL7309
CAS Type 1 Name: Benzenebutanoic acid, 4-(bis(2-chloroethyl)amino)-
DeCS ID: 2745
Unique ID: D002699
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1966/01/01
Date of Entry: 1999/01/01
Revision Date: 2016/07/01
Chlorambucil - Preferred
Concept UI M0004118
Scope note A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
Preferred term Chlorambucil
Entry term(s) 4-(Bis(2-chloroethyl)amino)benzenebutanoic Acid
Chloraminophene
Chlorbutin
N,N-Di-(2-chloroethyl)-p-aminophenylbutyric Acid
NSC-3088 - Narrower
Concept UI M0372321
Preferred term NSC-3088
Entry term(s) NSC 3088
NSC3088
Leukeran - Narrower
Concept UI M0004119
Preferred term Leukeran
Lympholysin - Narrower
Concept UI M0372322
Preferred term Lympholysin
Amboclorin - Narrower
Concept UI M0372324
Preferred term Amboclorin
CB-1348 - Narrower
Concept UI M0372323
Preferred term CB-1348
Entry term(s) CB 1348
CB1348



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