Search on: COCAINE 
Descriptors Found: 1
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Descriptor English:   Cocaine 
Descriptor Spanish:   Cocaína 
Descriptor Portuguese:   Cocaína 
Synonyms English:   Cocaine HCl
Cocaine Hydrochloride
HCl, Cocaine
Hydrochloride, Cocaine  
Tree Number:   D02.145.074.722.388
Definition English:   An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinically used for that purpose, particularly in the eye, ear, nose, and throat. It also has powerful central nervous system effects similar to the amphetamines and is a drug of abuse. Cocaine, like amphetamines, acts by multiple mechanisms on brain catecholaminergic neurons; the mechanism of its reinforcing effects is thought to involve inhibition of dopamine uptake. 
Indexing Annotation English:   cocaine derivatives = COCAINE /analogs; CRACK COCAINE, COCAINE SMOKING and COCAINE-RELATED DISORDERS are available
Pharmacological Action:   Anesthetics, Local
Vasoconstrictor Agents
Dopamine Uptake Inhibitors
See Related English:   Cocainum Hydrochloricum
History Note English:   COCAINE DERIVATIVES was see under COCAINE 1975-77; was see under TROPANES 1969-74 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AA analogs & derivatives
AN analysis AI antagonists & inhibitors
BI biosynthesis BL blood
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
EC economics GE genetics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PO poisoning RE radiation effects
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UR urine  
Record Number:   3070 
Unique Identifier:   D003042 

Occurrence in VHL: