Search on: CONOTOXINS 
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Descriptor English:   Conotoxins 
Descriptor Spanish:   Conotoxinas 
Descriptor Portuguese:   Conotoxinas 
Synonyms English:   Conotoxin
alpha Conotoxin
alpha Conotoxins
alpha-Conotoxin
alpha-Conotoxins
mu Conotoxin
mu Conotoxins
mu-Conotoxin
mu-Conotoxins  
Tree Number:   D20.888.590.162
D23.946.580.590.162
D23.946.833.590.162
Definition English:   Peptide neurotoxins from the marine fish-hunting snails of the genus CONUS. They contain 13 to 29 amino acids which are strongly basic and are highly cross-linked by disulfide bonds. There are three types of conotoxins, omega-, alpha-, and mu-. OMEGA-CONOTOXINS inhibit voltage-activated entry of calcium into the presynaptic membrane and therefore the release of ACETYLCHOLINE. Alpha-conotoxins inhibit the postsynaptic acetylcholine receptor. Mu-conotoxins prevent the generation of muscle action potentials. (From Concise Encyclopedia Biochemistry and Molecular Biology, 3rd ed) 
Indexing Annotation English:   OMEGA-CONOTOXINS and OMEGA-CONOTOXIN GVIA are available
Pharmacological Action:   Calcium Channel Blockers
Neurotoxins
 
History Note English:   2000 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AN analysis
AI antagonists & inhibitors BI biosynthesis
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification EC economics
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PO poisoning
RE radiation effects TU therapeutic use
TO toxicity UR urine
Record Number:   34514 
Unique Identifier:   D020916 

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