Search on: CYTOCHROME P-450 ENZYME SYSTEM 
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Descriptor English:   Cytochrome P-450 Enzyme System 
Descriptor Spanish:   Sistema Enzimático del Citocromo P-450 
Descriptor Portuguese:   Sistema Enzimático do Citocromo P-450 
Synonyms English:   CYP450 Family
CYP450 Superfamily
Cytochrome P 450
Cytochrome P 450 Dependent Monooxygenase
Cytochrome P 450 Enzyme System
Cytochrome P 450 Enzymes
Cytochrome P 450 Families
Cytochrome P 450 Monooxygenase
Cytochrome P 450 Oxygenase
Cytochrome P 450 Superfamily
Cytochrome P-450
Cytochrome P-450 Enzymes
Cytochrome P-450 Families
Cytochrome P-450 Monooxygenase
Cytochrome P-450 Oxygenase
Cytochrome P-450 Superfamily
Cytochrome P-450-Dependent Monooxygenase
Cytochrome P450
Cytochrome P450 Superfamily
Cytochrome p450 Families
Enzymes, Cytochrome P-450
Enzymes, P-450
Enzymes, P450
Monooxygenase, Cytochrome P-450
Monooxygenase, Cytochrome P-450-Dependent
P 450 Enzymes
P-450 Enzymes
P-450 Enzymes, Cytochrome
P450 Enzymes
Superfamily, CYP450
Superfamily, Cytochrome P-450
Superfamily, Cytochrome P450  
Tree Number:   D08.244.453
D08.811.682.690.708.170
D12.776.422.220.453
Definition English:   A superfamily of hundreds of closely related HEMEPROTEINS found throughout the phylogenetic spectrum, from animals, plants, fungi, to bacteria. They include numerous complex monooxygenases (MIXED FUNCTION OXYGENASES). In animals, these P-450 enzymes serve two major functions: (1) biosynthesis of steroids, fatty acids, and bile acids; (2) metabolism of endogenous and a wide variety of exogenous substrates, such as toxins and drugs (BIOTRANSFORMATION). They are classified, according to their sequence similarities rather than functions, into CYP gene families (>40% homology) and subfamilies (>59% homology). For example, enzymes from the CYP1, CYP2, and CYP3 gene families are responsible for most drug metabolism. 
Indexing Annotation English:   general or unspecified; prefer specific cytochrome P-450's
Entry Combination - descr/qualif English:   Cytochrome P-450 Enzyme System/antagonists & inhibitors use Cytochrome P-450 Enzyme Inhibitors
 
History Note English:   73; CYTOCHROME P-450 OXYGENASE was NM 1977-96 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AN analysis BI biosynthesis
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification DF deficiency
DE drug effects EC economics
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PH physiology
PO poisoning RE radiation effects
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UL ultrastructure UR urine
Record Number:   3595 
Unique Identifier:   D003577 

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