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Descriptor English:   DNA Restriction Enzymes 
Descriptor Spanish:   Enzimas de Restricción del ADN 
Descriptor Portuguese:   Enzimas de Restrição do DNA 
Synonyms English:   DNA Restriction Enzyme
Endonuclease, Restriction
Endonucleases, Restriction
Enzymes, DNA Restriction
Restriction Endonuclease
Restriction Endonucleases
Restriction Enzyme, DNA
Restriction Enzymes, DNA  
Tree Number:   D08.811.150.280
Definition English:   Enzymes that are part of the restriction-modification systems. They catalyze the endonucleolytic cleavage of DNA sequences which lack the species-specific methylation pattern in the host cell's DNA. Cleavage yields random or specific double-stranded fragments with terminal 5'-phosphates. The function of restriction enzymes is to destroy any foreign DNA that invades the host cell. Most have been studied in bacterial systems, but a few have been found in eukaryotic organisms. They are also used as tools for the systematic dissection and mapping of chromosomes, in the determination of base sequences of DNAs, and have made it possible to splice and recombine genes from one organism into the genome of another. EC 3.21.1. 
Indexing Annotation English:   DNA restriction enzyme used as a DNA marker: coord probably NIM with GENETIC MARKER (IM)
See Related English:   Polymorphism, Restriction Fragment Length
Restriction Mapping
History Note English:   79; was DNA RESTRICTION ENZYME 1978, was DNA RESTRICTION ENZYME see under ENDONUCLEASES 1975-77 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AN analysis AI antagonists & inhibitors
BI biosynthesis BL blood
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
DF deficiency DE drug effects
EC economics GE genetics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PH physiology PO poisoning
RE radiation effects ST standards
SD supply & distribution TU therapeutic use
TO toxicity UL ultrastructure
UR urine  
Record Number:   23985 
Unique Identifier:   D004262 

Occurrence in VHL: