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Descriptor English:   DNA Restriction-Modification Enzymes 
Descriptor Spanish:   Enzimas de Restricción-Modificación del ADN 
Descriptor Portuguese:   Enzimas de Restrição-Modificação do DNA 
Synonyms English:   DNA Restriction Modification Enzymes
Enzymes, DNA Restriction-Modification
Modification Systems, Restriction
Restriction Modification Systems
Restriction-Modification Enzymes, DNA
Restriction-Modification Systems
Systems, Restriction Modification
Systems, Restriction-Modification  
Tree Number:   D08.811.150
Definition English:   Systems consisting of two enzymes, a modification methylase and a restriction endonuclease. They are closely related in their specificity and protect the DNA of a given bacterial species. The methylase adds methyl groups to adenine or cytosine residues in the same target sequence that constitutes the restriction enzyme binding site. The methylation renders the target site resistant to restriction, thereby protecting DNA against cleavage. 
History Note English:   89 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AN analysis AI antagonists & inhibitors
BI biosynthesis BL blood
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
DF deficiency DE drug effects
EC economics GE genetics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PH physiology PO poisoning
RE radiation effects ST standards
SD supply & distribution TU therapeutic use
TO toxicity UL ultrastructure
UR urine  
Record Number:   23619 
Unique Identifier:   D015280 

Occurrence in VHL: