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Descriptor English:   DNA Topoisomerase IV 
Descriptor Spanish:   Topoisomerasa de ADN IV 
Descriptor Portuguese:   DNA Topoisomerase IV 
Synonyms English:   Topo IV
Topoisomerase IV
Topoisomerase IV Subunit A
Topoisomerase IV Subunit B
Topoisomerase IV, DNA
parC Gene Product
parC Gene Product, Topo IV
parC Protein
parE Gene Product
parE Gene Product, Topo IV
parE Protein  
Tree Number:   D08.811.399.403.741.224
Definition English:   A bacterial DNA topoisomerase II that catalyzes ATP-dependent breakage of both strands of DNA, passage of the unbroken strands through the breaks, and rejoining of the broken strands. Topoisomerase IV binds to DNA as a heterotetramer consisting 2 parC and 2 parE subunits. Topoisomerase IV is a decatenating enzyme that resolves interlinked daughter chromosomes following DNA replication. 
History Note English:   2002; use DNA TOPOISOMERASE IV (NM) 1991-2001 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AN analysis AI antagonists & inhibitors
BI biosynthesis BL blood
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
DF deficiency DE drug effects
EC economics GE genetics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PH physiology PO poisoning
RE radiation effects ST standards
SD supply & distribution TU therapeutic use
TO toxicity UL ultrastructure
UR urine  
Record Number:   36090 
Unique Identifier:   D027101 

Occurrence in VHL: