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Descriptor English:   DNA Topoisomerases 
Descriptor Spanish:   ADN-Topoisomerasas 
Descriptor Portuguese:   DNA Topoisomerases 
Synonyms English:   Topoisomerases, DNA  
Tree Number:   D08.811.399.403
Definition English:   Enzymes that regulate the topology of DNA by actions such as breaking, relaxing, passing, and rejoining strands of DNA in cells. These enzymes are important components of the DNA replication system. They are classified by their substrate specificities. DNA TOPOISOMERASE I enzymes act on a single strand of DNA. DNA TOPOISOMERASE II enzymes act on double strands of DNA. 
Entry Combination - descr/qualif English:   DNA Topoisomerases/antagonists & inhibitors use Topoisomerase Inhibitors
History Note English:   2002 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AN analysis BI biosynthesis
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification DF deficiency
DE drug effects EC economics
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PH physiology
PO poisoning RE radiation effects
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UL ultrastructure UR urine
Record Number:   36083 
Unique Identifier:   D026942 

Occurrence in VHL: