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Descriptor English:   DNA Topoisomerases, Type I 
Descriptor Spanish:   ADN-Topoisomerasas de Tipo I 
Descriptor Portuguese:   DNA Topoisomerases Tipo I 
Synonyms English:   DNA Nicking-Closing Protein
DNA Nicking-Closing Proteins
DNA Relaxing Enzyme
DNA Relaxing Enzymes
DNA Relaxing Protein
DNA Topoisomerase
DNA Topoisomerase I
DNA Topoisomerase III
DNA Topoisomerase III alpha
DNA Topoisomerase III beta
DNA Type 1 Topoisomerase
DNA Untwisting Enzyme
DNA Untwisting Enzymes
DNA Untwisting Protein
DNA Untwisting Proteins
III beta, Topoisomerase
III, DNA Topoisomerase
III, Topo
III, Topoisomerase
IIIalpha, TOPO
IIIalpha, Topoisomerase
IIIbeta, Topoisomerase
TOP3 Topoisomerase
Topo III
Topoisomerase I
Topoisomerase III
Topoisomerase III beta
Topoisomerase III, DNA
Topoisomerase IIIalpha
Topoisomerase IIIbeta
Topoisomerase, TOP3
Type I DNA Topoisomerase
beta, Topoisomerase III  
Tree Number:   D08.811.399.403.483
Definition English:   DNA TOPOISOMERASES that catalyze ATP-independent breakage of one of the two strands of DNA, passage of the unbroken strand through the break, and rejoining of the broken strand. DNA Topoisomerases, Type I enzymes reduce the topological stress in the DNA structure by relaxing the superhelical turns and knotted rings in the DNA helix. 
Indexing Annotation English:   do not confuse entry term DNA UNTWISTING PROTEIN with DNA UNWINDING PROTEINS see DNA HELICASES; coordinate with BACTERIAL PROTEINS or ARCHAEAL PROTEINS if pertinent
Entry Combination - descr/qualif English:   DNA Topoisomerases, Type I/antagonists & inhibitors use Topoisomerase I Inhibitors
History Note English:   2002 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AN analysis BI biosynthesis
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification DF deficiency
DE drug effects EC economics
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PH physiology
PO poisoning RE radiation effects
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UL ultrastructure UR urine
Record Number:   31732 
Unique Identifier:   D004264 

Occurrence in VHL: